4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylbenzaldehyde

Base Information

Chemical Name:4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylbenzaldehyde
CAS No.:1444174-22-4
Molecular Formula:C₁₈H₁₂Cl₂F₃NOS
Molecular Weight:418.267
Hs Code.:

Synonyms:4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylbenzaldehyde

Suppliers and Price of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylbenzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylbenzaldehyde

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylbenzaldehyde

There total 5 articles about 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1444176-97-9
[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methanol

: 1444174-22-4
4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylbenzaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 - 25 ℃;

Reference yield:

: 1444174-23-5
C₁₉H₁₄Cl₂F₃NO₂S

: 1444174-22-4
4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylbenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / 0 °C

1.2: 2 h / 20 - 25 °C

2.1: Dess-Martin periodane / dichloromethane / 20 - 25 °C

With diisobutylaluminium hydride; Dess-Martin periodane; In dichloromethane; toluene;

Reference yield:

: 943437-03-4
1-(4-bromo-3-methylphenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-en-1-one

: 1444174-22-4
4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylbenzaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; hydrogen sulfide / dichloromethane / 0.5 h / 0 °C

2.1: triethylamine; hydroxylamine-O-sulfonic acid / dichloromethane; water / 0.75 h / -15 - 0 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; sodium acetate / tetrahydrofuran / 13 h / 80 °C / 3750.38 - 5625.56 Torr / Inert atmosphere

4.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / 0 °C

4.2: 2 h / 20 - 25 °C

5.1: Dess-Martin periodane / dichloromethane / 20 - 25 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydrogen sulfide; sodium acetate; palladium diacetate; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; hydroxylamine-O-sulfonic acid; In tetrahydrofuran; dichloromethane; water; toluene;