[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methanol

Base Information

Chemical Name:[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methanol
CAS No.:1444176-97-9
Molecular Formula:C₁₈H₁₄Cl₂F₃NOS
Molecular Weight:420.282
Hs Code.:

Synonyms:[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methanol

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Chemical Property of [4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methanol

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Technology Process of [4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methanol

There total 4 articles about [4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1444174-23-5
C₁₉H₁₄Cl₂F₃NO₂S

: 1444176-97-9
[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methanol

Guidance literature:: C₁₉H₁₄Cl₂F₃NO₂S; With diisobutylaluminium hydride; In dichloromethane; toluene; at 0 ℃; for 1.5h;

With rochelle salt; In methanol; at 20 - 25 ℃; for 2h;

Reference yield:

: 1427274-60-9
1-(4-bromo-3-methyl-phenyl)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butan-1-one

: 1444176-97-9
[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; hydroxylamine-O-sulfonic acid / dichloromethane; water / 0.75 h / -15 - 0 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; sodium acetate / tetrahydrofuran / 13 h / 80 °C / 3750.38 - 5625.56 Torr / Inert atmosphere

3.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / 0 °C

3.2: 2 h / 20 - 25 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium acetate; palladium diacetate; diisobutylaluminium hydride; triethylamine; hydroxylamine-O-sulfonic acid; In tetrahydrofuran; dichloromethane; water; toluene;

Reference yield:

: 943437-03-4
1-(4-bromo-3-methylphenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-en-1-one

: 1444176-97-9
[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methylphenyl]methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; hydrogen sulfide / dichloromethane / 0.5 h / 0 °C

2.1: triethylamine; hydroxylamine-O-sulfonic acid / dichloromethane; water / 0.75 h / -15 - 0 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; sodium acetate / tetrahydrofuran / 13 h / 80 °C / 3750.38 - 5625.56 Torr / Inert atmosphere

4.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / 0 °C

4.2: 2 h / 20 - 25 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydrogen sulfide; sodium acetate; palladium diacetate; diisobutylaluminium hydride; triethylamine; hydroxylamine-O-sulfonic acid; In tetrahydrofuran; dichloromethane; water; toluene;