N-(4-chlorophenyl)-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

Base Information

• Chemical Name: N-(4-chlorophenyl)-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
• CAS No.: 330453-93-5
• Molecular Formula: C₁₈H₁₆ClN₃O₂
• Molecular Weight: 341.797

Synonyms:N-(4-chlorophenyl)-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

Chemical Property of N-(4-chlorophenyl)-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

Chemical Property:

Purity/Quality:

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• Pictogram(s):  
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Technology Process of N-(4-chlorophenyl)-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

There total 2 articles about N-(4-chlorophenyl)-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4'-Chloroacetoacetanilide (101-92-8) + benzaldehyde (100-52-7) + urea (57-13-6) → N-(4-chlorophenyl)-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide (330453-93-5)

Guidance literature:

With acidine; at 80 ℃; for 0.25h; Green chemistry;

DOI:10.1002/cjoc.201500862

Reference yield:

4-chloro-aniline (106-47-8) → N-(4-chlorophenyl)-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide (330453-93-5)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene

2: ethanol / Acidic conditions; Reflux

In ethanol; toluene; 2: |Biginelli Pyrimidone Synthesis;

DOI:10.1111/cbdd.12373

Reference yield: 89.0%

N-(4-chlorophenyl)-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide (330453-93-5) → N-(4-chlorophenyl)-6-methyl-2-oxo-4-phenyl-1,2-dihydropyrimidine-5-carboxamide (1273558-52-3)

Guidance literature:

With (Bu₄N)₂S₂O₈; In acetonitrile; at 74 ℃; for 0.0833333h; Sonication;

DOI:10.1016/j.ultsonch.2010.10.006

upstream raw materials:

4'-Chloroacetoacetanilide

benzaldehyde

urea

4-chloro-aniline

Downstream raw materials:

N-(4-chlorophenyl)-6-methyl-2-oxo-4-phenyl-1,2-dihydropyrimidine-5-carboxamide

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