(S)-benzyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

Base Information

Chemical Name:(S)-benzyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate
CAS No.:1351168-05-2
Molecular Formula:C₂₄H₂₇F₂N₃O₅S
Molecular Weight:507.558
Hs Code.:

Synonyms:(S)-benzyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

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Chemical Property of (S)-benzyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

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Technology Process of (S)-benzyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

There total 7 articles about (S)-benzyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1351167-90-2
(S)-benzyl 4-(3-amino-2-oxopyrrolidin-1-yl)piperidin-1-carboxylate

: 845616-49-1
1,2,4-trifluoro-5-(methylsulfonyl)benzene

: 1351168-05-2
(S)-benzyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

Guidance literature:: With sodium carbonate; In dimethyl sulfoxide; at 130 ℃; for 18h; Inert atmosphere; Sealed tube;

Reference yield:

: 120278-07-1
benzyl 4-aminopiperidine-1-carboxylate

: 1351168-05-2
(S)-benzyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 18 h / 20 °C

2.1: 4 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: sodium carbonate / dimethyl sulfoxide / 18 h / 130 °C / Inert atmosphere; Sealed tube

With sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 845616-48-0
2,4,5-trifluorobenzenesulfinic acid

: 1351168-05-2
(S)-benzyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: sodium carbonate / dimethyl sulfoxide / 18 h / 130 °C / Inert atmosphere; Sealed tube

With sodium carbonate; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide;