(S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1-(piperidin-4-yl)pyrrolidin-2-one

Base Information

Chemical Name:(S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1-(piperidin-4-yl)pyrrolidin-2-one
CAS No.:1351167-92-4
Molecular Formula:C₁₆H₂₁F₂N₃O₃S
Molecular Weight:373.424
Hs Code.:

Synonyms:(S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1-(piperidin-4-yl)pyrrolidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1-(piperidin-4-yl)pyrrolidin-2-one

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Technology Process of (S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1-(piperidin-4-yl)pyrrolidin-2-one

There total 10 articles about (S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1-(piperidin-4-yl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1351168-05-2
(S)-benzyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

: 1351167-92-4
(S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1-(piperidin-4-yl)pyrrolidin-2-one

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; for 18h;

Reference yield:

: 120278-07-1
benzyl 4-aminopiperidine-1-carboxylate

: 1351167-92-4
(S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1-(piperidin-4-yl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 18 h / 20 °C

2.1: 4 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: sodium carbonate / dimethyl sulfoxide / 18 h / 130 °C / Inert atmosphere; Sealed tube

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 18 h

With hydrogen; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 845616-48-0
2,4,5-trifluorobenzenesulfinic acid

: 1351167-92-4
(S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1-(piperidin-4-yl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: sodium carbonate / dimethyl sulfoxide / 18 h / 130 °C / Inert atmosphere; Sealed tube

3: hydrogen / palladium 10% on activated carbon / ethanol / 18 h

With hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;