3H-Indol-3-one, 1-acetyl-2-[(4-bromophenyl)chloromethyl]-2-chloro-1,2-dihydro-

Base Information

• Chemical Name: 3H-Indol-3-one, 1-acetyl-2-[(4-bromophenyl)chloromethyl]-2-chloro-1,2-dihydro-
• CAS No.: 144294-78-0
• Molecular Formula: C₁₇H₁₂BrCl₂NO₂
• Molecular Weight: 413.098
• Mol file: 144294-78-0.mol

Synonyms:3H-Indol-3-one, 1-acetyl-2-[(4-bromophenyl)chloromethyl]-2-chloro-1,2-dihydro-

Chemical Property of 3H-Indol-3-one, 1-acetyl-2-[(4-bromophenyl)chloromethyl]-2-chloro-1,2-dihydro-

Chemical Property:

• PSA: 37.38000
• LogP: 4.97850

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3H-Indol-3-one, 1-acetyl-2-[(4-bromophenyl)chloromethyl]-2-chloro-1,2-dihydro-

There total 1 articles about 3H-Indol-3-one, 1-acetyl-2-[(4-bromophenyl)chloromethyl]-2-chloro-1,2-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-acetyl-2-(4-bromobenzylidene)indolin-3-one (96682-70-1) → 1-Acetyl-2-[(4-bromo-phenyl)-chloro-methyl]-2-chloro-1,2-dihydro-indol-3-one (144294-78-0)

Guidance literature:

With chlorine; In chloroform;

DOI:10.1007/BF00473954

Reference yield:

1-Acetyl-2-[(4-bromo-phenyl)-chloro-methyl]-2-chloro-1,2-dihydro-indol-3-one (144294-78-0) → 4'-bromo-1H-2-phenyl-3-hydroxy-4-oxoquinoline (144294-89-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOMe / dioxane

2: aq. AcOH / Heating

With sodium methylate; acetic acid; In 1,4-dioxane;

DOI:10.1007/BF00473954

Reference yield:

1-Acetyl-2-[(4-bromo-phenyl)-chloro-methyl]-2-chloro-1,2-dihydro-indol-3-one (144294-78-0) → 2-(4-bromophenyl)-3-methoxyquinolin-4(1H)-one (144294-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOMe / dioxane

2: HCl / Heating

With hydrogenchloride; sodium methylate; In 1,4-dioxane;

DOI:10.1007/BF00473954

upstream raw materials:

1-acetyl-2-(4-bromobenzylidene)indolin-3-one

Downstream raw materials:

4'-bromo-1H-2-phenyl-3-hydroxy-4-oxoquinoline

2-(4-bromophenyl)-3-methoxyquinolin-4(1H)-one