5-cyclopropyl-2-(4-(4-fluorophenoxy)phenyl)-6-(N-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

Base Information

Chemical Name:5-cyclopropyl-2-(4-(4-fluorophenoxy)phenyl)-6-(N-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide
CAS No.:1378427-73-6
Molecular Formula:C₃₄H₃₀BFN₂O₇S
Molecular Weight:640.497
Hs Code.:

5-cyclopropyl-2-(4-(4-fluorophenoxy)phenyl)-6-(N-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

Synonyms:5-cyclopropyl-2-(4-(4-fluorophenoxy)phenyl)-6-(N-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

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Chemical Property of 5-cyclopropyl-2-(4-(4-fluorophenoxy)phenyl)-6-(N-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

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Technology Process of 5-cyclopropyl-2-(4-(4-fluorophenoxy)phenyl)-6-(N-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

There total 10 articles about 5-cyclopropyl-2-(4-(4-fluorophenoxy)phenyl)-6-(N-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1378430-91-1
methyl 5-((N-((5-cyclopropyl-2-(4-(4-fluorophenoxy)phenyl)-3-(methylcarbamoyl)benzofuran-6-yl))methylsulfonamido)methyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 1378427-73-6
5-cyclopropyl-2-(4-(4-fluorophenoxy)phenyl)-6-(N-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

Guidance literature:: methyl 5-((N-((5-cyclopropyl-2-(4-(4-fluorophenoxy)phenyl)-3-(methylcarbamoyl)benzofuran-6-yl))methylsulfonamido)methyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; With lithium borohydride; In tetrahydrofuran; at 0 ℃; for 1.5h;

With water; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 1179986-78-7
5-cyclopropyl-2-[4-(4-fluoro-phenoxy)-phenyl]-6-methanesulfonylamino-benzofuran-3-carboxylic acid

: 1378427-73-6
5-cyclopropyl-2-(4-(4-fluorophenoxy)phenyl)-6-(N-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 2 h

2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 24 h / Inert atmosphere

4.1: lithium borohydride / tetrahydrofuran / 1.5 h / 0 °C

With lithium borohydride; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 1179985-58-0
5-cyclopropyl-2-[4-(4-fluoro-phenoxy)-phenyl]-6-methanesulfonylamino-benzofuran-3-carboxylic acid methylamide

: 1378427-73-6
5-cyclopropyl-2-(4-(4-fluorophenoxy)phenyl)-6-(N-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 24 h / Inert atmosphere

3: lithium borohydride / tetrahydrofuran / 1.5 h / 0 °C

With lithium borohydride; potassium acetate; potassium carbonate; potassium iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;