ethyl 2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate

Base Information

Chemical Name:ethyl 2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate
CAS No.:1179986-66-3
Molecular Formula:C₂₆H₂₂FNO₇
Molecular Weight:479.462
Hs Code.:

Synonyms:ethyl 2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate

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Chemical Property of ethyl 2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate

Chemical Property:

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Technology Process of ethyl 2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate

There total 5 articles about ethyl 2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 371-41-5
4-Fluorophenol

: 1179986-65-2
ethyl 2-(4-bromophenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate

: 1179986-66-3
ethyl 2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate

Guidance literature:: With potassium phosphate; palladium diacetate; tert-butyl XPhos; In toluene; at 100 ℃; for 2h; Inert atmosphere;

Reference yield:

: 99-90-1
para-bromoacetophenone

: 1179986-66-3
ethyl 2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / toluene; mineral oil / 2 h / 0 - 20 °C

1.2: Reflux

2.1: zinc(II) chloride / N,N-dimethyl-formamide / 3.5 h / 105 °C

3.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 0.33 h / 20 °C

3.2: 4 h / 80 °C

4.1: nitric acid / dichloromethane / 1.5 h / 0 - 20 °C

5.1: potassium phosphate / palladium diacetate; tert-butyl XPhos / toluene / 2 h / 100 °C / Inert atmosphere

With potassium phosphate; nitric acid; sodium hydride; caesium carbonate; zinc(II) chloride; palladium diacetate; tert-butyl XPhos; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 26510-95-2
ethyl 4-Bromobenzoylacetate

: 1179986-66-3
ethyl 2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc(II) chloride / N,N-dimethyl-formamide / 3.5 h / 105 °C

2.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 0.33 h / 20 °C

2.2: 4 h / 80 °C

3.1: nitric acid / dichloromethane / 1.5 h / 0 - 20 °C

4.1: potassium phosphate / palladium diacetate; tert-butyl XPhos / toluene / 2 h / 100 °C / Inert atmosphere

With potassium phosphate; nitric acid; caesium carbonate; zinc(II) chloride; palladium diacetate; tert-butyl XPhos; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; toluene;