Technology Process of ethyl 2-(4-(4-fluorophenoxy)phenyl)-5-hydroxy-6-nitrobenzofuran-3-carboxylate
There total 6 articles about ethyl 2-(4-(4-fluorophenoxy)phenyl)-5-hydroxy-6-nitrobenzofuran-3-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate;
With
boron trichloride;
In
dichloromethane;
for 0.333333h;
Cooling with ice;
Inert atmosphere;
With
water;
In
dichloromethane;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / toluene; mineral oil / 2 h / 0 - 20 °C
1.2: Reflux
2.1: zinc(II) chloride / N,N-dimethyl-formamide / 3.5 h / 105 °C
3.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 0.33 h / 20 °C
3.2: 4 h / 80 °C
4.1: nitric acid / dichloromethane / 1.5 h / 0 - 20 °C
5.1: potassium phosphate / palladium diacetate; tert-butyl XPhos / toluene / 2 h / 100 °C / Inert atmosphere
6.1: boron trichloride / dichloromethane / -78 - -40 °C
With
potassium phosphate; nitric acid; boron trichloride; sodium hydride; caesium carbonate; zinc(II) chloride;
palladium diacetate; tert-butyl XPhos;
In
1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: zinc(II) chloride / N,N-dimethyl-formamide / 3.5 h / 105 °C
2.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 0.33 h / 20 °C
2.2: 4 h / 80 °C
3.1: nitric acid / dichloromethane / 1.5 h / 0 - 20 °C
4.1: potassium phosphate / palladium diacetate; tert-butyl XPhos / toluene / 2 h / 100 °C / Inert atmosphere
5.1: boron trichloride / dichloromethane / -78 - -40 °C
With
potassium phosphate; nitric acid; boron trichloride; caesium carbonate; zinc(II) chloride;
palladium diacetate; tert-butyl XPhos;
In
1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; toluene;
