4,6-dimethyl-3-phenylpyridin-2-yl nonaflate

Base Information

• Chemical Name: 4,6-dimethyl-3-phenylpyridin-2-yl nonaflate
• CAS No.: 1547432-33-6
• Molecular Formula: C₁₇H₁₂F₉NO₃S
• Molecular Weight: 481.339
• Mol file: 1547432-33-6.mol

Synonyms:4,6-dimethyl-3-phenylpyridin-2-yl nonaflate

Chemical Property of 4,6-dimethyl-3-phenylpyridin-2-yl nonaflate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4,6-dimethyl-3-phenylpyridin-2-yl nonaflate

There total 13 articles about 4,6-dimethyl-3-phenylpyridin-2-yl nonaflate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

Nonafluorobutanesulfonyl fluoride (375-72-4) + 4,6-dimethyl-3-phenylpyridin-2(1H)-one (107622-90-2) → 4,6-dimethyl-3-phenylpyridin-2-yl nonaflate (1547432-33-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1055/s-0033-1338548

Reference yield: 20.0%

Nonafluorobutanesulfonyl fluoride (375-72-4) + (Z)-N-(4-oxopent-2-en-2-yl)-2-phenylacetamide (1547432-67-6) → 2-benzyl-6-methylpyridin-4-yl nonaflate (1547432-27-8) + 4,6-dimethyl-3-phenylpyridin-2-yl nonaflate (1547432-33-6)

Guidance literature:

(Z)-N-(4-oxopent-2-en-2-yl)-2-phenylacetamide; With trimethylsilyl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 90 ℃; for 72h; Sealed tube; Inert atmosphere;

Nonafluorobutanesulfonyl fluoride; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; Inert atmosphere;

DOI:10.1055/s-0033-1338548

Reference yield:

4-Aminopent-3-en-2-one (1118-66-7) → 4,6-dimethyl-3-phenylpyridin-2-yl nonaflate (1547432-33-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: sodium hydride / tetrahydrofuran; mineral oil / 24 h / 20 °C / Inert atmosphere

With potassium tert-butylate; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1055/s-0033-1338548

upstream raw materials:

4-Aminopent-3-en-2-one

acetylacetone

Nonafluorobutanesulfonyl fluoride

4,6-dimethyl-3-phenylpyridin-2(1H)-one

Refernces