5-Methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 5-Methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine
• CAS No.: 144042-79-5
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.197
• European Community (EC) Number: 855-299-8
• ChEMBL ID: CHEMBL4565706
• Mol file: 144042-79-5.mol

Synonyms:144042-79-5;5-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine;Imidazo[1,2-a]pyridine, 5,6,7,8-tetrahydro-5-methyl- (9CI);5-methyl-5H,6H,7H,8H-imidazo[1,2-a]pyridine;CHEMBL4565706;SCHEMBL13755326;CS-0102364;EN300-251066

Chemical Property of 5-Methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

Chemical Property:

• Boiling Point: 282.4±9.0 °C(Predicted)
• PKA: 7.77±0.40(Predicted)
• PSA: 17.82000
• Density: 1.14±0.1 g/cm3(Predicted)
• LogP: 1.78040
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 136.100048391
• Heavy Atom Count: 10
• Complexity: 124

Purity/Quality:

99% ^*data from raw suppliers

5-methyl-5H,6H,7H,8H-imidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CCCC2=NC=CN12

Technology Process of 5-Methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

There total 3 articles about 5-Methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methylimidazo[1,2-a]pyridine (933-69-7) → 5-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine (144042-79-5)

Guidance literature:

With hydrogen; nickel; In butan-1-ol; at 65 ℃; for 24h; under 3102.9 Torr;

DOI:10.1021/jm00101a019

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) → 5-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine (144042-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium bicarbonate / H₂O / 72 h / Ambient temperature

2: H₂ / Raney nickel / butan-1-ol / 24 h / 65 °C / 3102.9 Torr

With hydrogen; sodium hydrogencarbonate; nickel; In water; butan-1-ol;

DOI:10.1021/jm00101a019

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) → 5-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine (144042-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: water; ethanol / 2 h / 100 °C / Sealed tube; Inert atmosphere

2: [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); potassium tert-butylate; C₁₅H₂₅N₂*ClH; hydrogen / tert-Amyl alcohol / 24 h / 25 - 70 °C / 75007.5 Torr / Autoclave

With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); C₁₅H₂₅N₂*ClH; potassium tert-butylate; hydrogen; In tert-Amyl alcohol; ethanol; water;

DOI:10.1002/chem.201705370

upstream raw materials:

5-methylimidazo[1,2-a]pyridine

2-Amino-6-methylpyridine