(E)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-acrylic ethyl ester

Base Information

Chemical Name:(E)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-acrylic ethyl ester
CAS No.:174258-89-0
Molecular Formula:C₂₃H₂₀F₃NO₄
Molecular Weight:431.411
Hs Code.:

Synonyms:(E)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-acrylic ethyl ester

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Chemical Property of (E)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-acrylic ethyl ester

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Technology Process of (E)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-acrylic ethyl ester

There total 5 articles about (E)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-acrylic ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 174258-10-7
3-([5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl]methoxy)benzaldehyde

: 174258-89-0
(E)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-acrylic ethyl ester

Guidance literature:: In tetrahydrofuran; toluene;

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 174258-89-0
(E)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-acrylic ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 65 percent / HCl gas / ethyl acetate / 3 h / 5 °C

2.1: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

3.1: 65 percent / K₂CO₃ / dimethylformamide / 3 h / 80 °C

4.1: NaH / toluene / 1 h

4.2: toluene; tetrahydrofuran / 48 h

With hydrogenchloride; sodium hydride; potassium carbonate; trichlorophosphate; In chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: Condensation / 2.1: Chlorination / 3.1: Alkylation / 4.1: Metallation / 4.2: Condensation;
DOI:10.1021/jm990476x

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 174258-89-0
(E)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-acrylic ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 65 percent / K₂CO₃ / dimethylformamide / 3 h / 80 °C

2.1: NaH / toluene / 1 h

2.2: toluene; tetrahydrofuran / 48 h

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; toluene; 1.1: Alkylation / 2.1: Metallation / 2.2: Condensation;
DOI:10.1021/jm990476x