(S)-N²-tert-butoxycarbonyl-N¹-[1-ethoxycarbonyl-3-(3-bromophenyl)-2-oxopropyl]valinamide

Base Information

• Chemical Name: (S)-N²-tert-butoxycarbonyl-N¹-[1-ethoxycarbonyl-3-(3-bromophenyl)-2-oxopropyl]valinamide
• CAS No.: 866270-08-8
• Molecular Formula: C₂₂H₃₁BrN₂O₆
• Molecular Weight: 499.402

Synonyms:(S)-N²-tert-butoxycarbonyl-N¹-[1-ethoxycarbonyl-3-(3-bromophenyl)-2-oxopropyl]valinamide

Chemical Property of (S)-N²-tert-butoxycarbonyl-N¹-[1-ethoxycarbonyl-3-(3-bromophenyl)-2-oxopropyl]valinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N²-tert-butoxycarbonyl-N¹-[1-ethoxycarbonyl-3-(3-bromophenyl)-2-oxopropyl]valinamide

There total 7 articles about (S)-N²-tert-butoxycarbonyl-N¹-[1-ethoxycarbonyl-3-(3-bromophenyl)-2-oxopropyl]valinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

ethyl 4-(3-bromophenyl)-2-diazo-3-oxobutanoate (866270-05-5) → (S)-N2-tert-butoxycarbonyl-N1-[1-ethoxycarbonyl-3-(3-bromophenyl)-2-oxopropyl]valinamide (866270-08-8)

Guidance literature:

With rhodium (II) octanoate dimer; In dichloromethane; Heating;

DOI:10.1021/jo0509760

Reference yield:

3-Bromophenylacetic acid (1878-67-7) → (S)-N2-tert-butoxycarbonyl-N1-[1-ethoxycarbonyl-3-(3-bromophenyl)-2-oxopropyl]valinamide (866270-08-8)

Guidance literature:

Multi-step reaction with 6 steps

1: thionyl chloride / toluene / 1 h / Heating

2: 4.9 g / Et₃N / CH₂Cl₂ / 20 °C

3: LiAlH₄ / diethyl ether / 0.5 h / 0 °C

4: 71 percent / SnCl₂ / CH₂Cl₂ / 4 h

5: 92 percent / 4-acetamidobenzenesulfonyl azide / acetonitrile / 16 h / 20 °C

6: 73 percent / dirhodium tetraoctanoate / CH₂Cl₂ / Heating

With lithium aluminium tetrahydride; thionyl chloride; rhodium (II) octanoate dimer; 4-acetamidobenzenesulfonyl azide; triethylamine; tin(ll) chloride; In diethyl ether; dichloromethane; toluene; acetonitrile;

DOI:10.1021/jo0509760

Reference yield:

2-(3-bromophenyl)-N-methoxy-N-methylacetamide (866270-03-3) → (S)-N2-tert-butoxycarbonyl-N1-[1-ethoxycarbonyl-3-(3-bromophenyl)-2-oxopropyl]valinamide (866270-08-8)

Guidance literature:

Multi-step reaction with 4 steps

1: LiAlH₄ / diethyl ether / 0.5 h / 0 °C

2: 71 percent / SnCl₂ / CH₂Cl₂ / 4 h

3: 92 percent / 4-acetamidobenzenesulfonyl azide / acetonitrile / 16 h / 20 °C

4: 73 percent / dirhodium tetraoctanoate / CH₂Cl₂ / Heating

With lithium aluminium tetrahydride; rhodium (II) octanoate dimer; 4-acetamidobenzenesulfonyl azide; tin(ll) chloride; In diethyl ether; dichloromethane; acetonitrile;

DOI:10.1021/jo0509760

upstream raw materials:

ethyl 4-(3-bromophenyl)-2-diazo-3-oxobutanoate

2-(3-bromophenyl)-N-methoxy-N-methylacetamide

ethyl 4-(3-bromophenyl)-3-oxobutanoate

3-Bromophenylacetic acid

Downstream raw materials:

(S)-ethyl 5-(3-bromobenzyl)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]oxazole-4-carboxylate

(S)-5-[3-(1-tert-butoxycarbonyl-3-formylindol-4-yl)benzyl]-2-[(1-tert-butoxycarbonylamino)-2-methylpropyl]oxazole-4-carboxamide

(S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]-5-(3-bromobenzyl)oxazole-4-carboxamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 866270-08-8 (S)-N²-tert-butoxycarbonyl-N¹-[1-ethoxycarbonyl-3-(3-bromophenyl)-2-oxopropyl]valinamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send