N₁-[(5''-acetoxyethoxy)methyl]-N₉-[(5'-hydroxylethoxy)methyl]-8-trifluoromethylhypoxanthine

Base Information

• Chemical Name: N₁-[(5''-acetoxyethoxy)methyl]-N₉-[(5'-hydroxylethoxy)methyl]-8-trifluoromethylhypoxanthine
• CAS No.: 1256827-36-7
• Molecular Formula: C₁₄H₁₇F₃N₄O₆
• Molecular Weight: 394.307

Synonyms:N₁-[(5''-acetoxyethoxy)methyl]-N₉-[(5'-hydroxylethoxy)methyl]-8-trifluoromethylhypoxanthine

Chemical Property of N₁-[(5''-acetoxyethoxy)methyl]-N₉-[(5'-hydroxylethoxy)methyl]-8-trifluoromethylhypoxanthine

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Technology Process of N₁-[(5''-acetoxyethoxy)methyl]-N₉-[(5'-hydroxylethoxy)methyl]-8-trifluoromethylhypoxanthine

There total 1 articles about N₁-[(5''-acetoxyethoxy)methyl]-N₉-[(5'-hydroxylethoxy)methyl]-8-trifluoromethylhypoxanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2,2-difluoro-2-(fluorosulfonyl)acetate (680-15-9) + N1-[(5''-acetoxyethoxy)methyl]-N9-[(5'-tert-butyldiphenylsilyloxyethoxy)methyl]-8-bromohypoxanthine (1256827-34-5) → N1-[(5''-acetoxyethoxy)methyl]-N9-[(5'-hydroxylethoxy)methyl]-8-trifluoromethylhypoxanthine (1256827-36-7) + N1-[(5''-acetoxyethoxy)methyl]-N9-[(5'-tert-butyldiphenylsilyloxyethoxy)methyl]-8-trifluoromethylhypoxanthine (1256827-35-6)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; In N,N-dimethyl-formamide; at 70 ℃; for 20h; Inert atmosphere;

DOI:10.3390/molecules15128689

Reference yield: 79.0%

N1-[(5''-acetoxyethoxy)methyl]-N9-[(5'-hydroxylethoxy)methyl]-8-trifluoromethylhypoxanthine (1256827-36-7) + (S,S')-diphenylphosphorodithioate (23282-01-1) → N1-[(5''-acetoxyethoxy)methyl]-N9-[[5'-bis(phenylthio)phosphoryloxyethoxy]methyl]-8-trifluoromethylhypoxanthine (1256827-37-8)

Guidance literature:

With 1H-tetrazole; 2,4,6-triisopropylphenylsulfonyl chloride; In pyridine; at 20 ℃; for 12h;

DOI:10.3390/molecules15128689

upstream raw materials:

2,2-difluoro-2-(fluorosulfonyl)acetate

N₁-[(5''-acetoxyethoxy)methyl]-N₉-[(5'-tert-butyldiphenylsilyloxyethoxy)methyl]-8-bromohypoxanthine

Downstream raw materials:

N₁-[(5''-acetoxyethoxy)methyl]-N₉-[[5'-bis(phenylthio)phosphoryloxyethoxy]methyl]-8-trifluoromethylhypoxanthine

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