4-(benzyloxy)-N₁,N₁-dimethyl-N₃-(pyridin-3-yl)isophthalamide

Base Information

Chemical Name:4-(benzyloxy)-N₁,N₁-dimethyl-N₃-(pyridin-3-yl)isophthalamide
CAS No.:1285513-99-6
Molecular Formula:C₂₂H₂₁N₃O₃
Molecular Weight:375.427
Hs Code.:

4-(benzyloxy)-N<sub>1</sub>,N<sub>1</sub>-dimethyl-N<sub>3</sub>-(pyridin-3-yl)isophthalamide

Synonyms:4-(benzyloxy)-N₁,N₁-dimethyl-N₃-(pyridin-3-yl)isophthalamide

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Chemical Property of 4-(benzyloxy)-N₁,N₁-dimethyl-N₃-(pyridin-3-yl)isophthalamide

Chemical Property:

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Technology Process of 4-(benzyloxy)-N₁,N₁-dimethyl-N₃-(pyridin-3-yl)isophthalamide

There total 9 articles about 4-(benzyloxy)-N₁,N₁-dimethyl-N₃-(pyridin-3-yl)isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.8%

: 462-08-8
pyridin-3-ylamine

: 1285516-64-4
2-(benzyloxy)-5-(dimethylcarbamoyl)benzoic acid

: 1285513-99-6
4-(benzyloxy)-N₁,N₁-dimethyl-N₃-(pyridin-3-yl)isophthalamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2017.07.052

Reference yield:

: 1285516-45-1
3-[(methyloxy)carbonyl]-4-[(phenylmethyl)oxy]benzoic acid

: 1285513-99-6
4-(benzyloxy)-N₁,N₁-dimethyl-N₃-(pyridin-3-yl)isophthalamide

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2: dichloromethane / 2 h / 20 °C

3: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With oxalyl dichloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 636-46-4
4-hydroxyisophthalic acid

: 1285513-99-6
4-(benzyloxy)-N₁,N₁-dimethyl-N₃-(pyridin-3-yl)isophthalamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / acetone / 50 °C

2: water; lithium hydroxide / tetrahydrofuran / 20 °C

3: sulfuric acid / 3 h / 20 °C

4: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

5: dichloromethane / 2 h / 20 °C

6: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

7: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With oxalyl dichloride; sulfuric acid; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;