(2-amino-3-methoxyphenyl)(5-(trifluoromethyl)pyridin-2-yl)methanone

Base Information

• Chemical Name: (2-amino-3-methoxyphenyl)(5-(trifluoromethyl)pyridin-2-yl)methanone
• CAS No.: 1584648-12-3
• Molecular Formula: C₁₄H₁₁F₃N₂O₂
• Molecular Weight: 296.249
• Mol file: 1584648-12-3.mol

Synonyms:(2-amino-3-methoxyphenyl)(5-(trifluoromethyl)pyridin-2-yl)methanone

Chemical Property of (2-amino-3-methoxyphenyl)(5-(trifluoromethyl)pyridin-2-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-amino-3-methoxyphenyl)(5-(trifluoromethyl)pyridin-2-yl)methanone

There total 2 articles about (2-amino-3-methoxyphenyl)(5-(trifluoromethyl)pyridin-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tert-butyl (2-methoxy-6-(5-(trifluoromethyl)picolinoyl)phenyl)carbamate (1584648-13-4) → (2-amino-3-methoxyphenyl)(5-(trifluoromethyl)pyridin-2-yl)methanone (1584648-12-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 2h;

Reference yield:

5-(trifluoromethyl)-pyridine-2-carboxylic acid methyl ester (124236-37-9) + tert-butyl 2-methoxyphenylcarbamate (154150-18-2) → (2-amino-3-methoxyphenyl)(5-(trifluoromethyl)pyridin-2-yl)methanone (1584648-12-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / diethyl ether / 2 h / -23 °C / Inert atmosphere

1.2: 3 h / -78 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h

With tert.-butyl lithium; trifluoroacetic acid; In diethyl ether; dichloromethane;

upstream raw materials:

5-(trifluoromethyl)-pyridine-2-carboxylic acid methyl ester

tert-butyl 2-methoxyphenylcarbamate

tert-butyl (2-methoxy-6-(5-(trifluoromethyl)picolinoyl)phenyl)carbamate