{2-fluoro-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-cyclohex-1-enyl]-phenyl}-carbamic acid benzyl ester

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Chemical Name:{2-fluoro-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-cyclohex-1-enyl]-phenyl}-carbamic acid benzyl ester
CAS No.:1350444-85-7
Molecular Formula:C₂₅H₂₉FN₂O₂
Molecular Weight:408.516
Hs Code.:

Synonyms:{2-fluoro-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-cyclohex-1-enyl]-phenyl}-carbamic acid benzyl ester

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Chemical Property of {2-fluoro-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-cyclohex-1-enyl]-phenyl}-carbamic acid benzyl ester

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Technology Process of {2-fluoro-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-cyclohex-1-enyl]-phenyl}-carbamic acid benzyl ester

There total 5 articles about {2-fluoro-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-cyclohex-1-enyl]-phenyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350445-24-7
methanesulfonic acid 4-(4-benzyloxycarbonylamino-3-fluoro-phenyl)-cyclohex-3-enyl ester

: 765-38-8,41720-98-3,59335-84-1,79171-53-2
(S)-2-methylpyrrolidine

: 1350444-85-7
{2-fluoro-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-cyclohex-1-enyl]-phenyl}-carbamic acid benzyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃; for 16h; Inert atmosphere;

Reference yield:

: 865869-24-5
trifluoro-methanesulfonic acid 4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enyl ester

: 1350444-85-7
{2-fluoro-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-cyclohex-1-enyl]-phenyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 0.67 h / 100 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 - 60 °C

3: triethylamine / dichloromethane / 1 h / Inert atmosphere; Cooling with ice

4: potassium carbonate / acetonitrile / 16 h / 80 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; triethylamine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 55145-45-4
4-(tert-butyldimethylsilyloxy)cyclohexanone

: 1350444-85-7
{2-fluoro-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-cyclohex-1-enyl]-phenyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 2 h / -78 °C

2.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 0.67 h / 100 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 - 60 °C

4.1: triethylamine / dichloromethane / 1 h / Inert atmosphere; Cooling with ice

5.1: potassium carbonate / acetonitrile / 16 h / 80 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; triethylamine; lithium chloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; toluene; acetonitrile;