865869-24-5Relevant academic research and scientific papers
Electrochemical Synthesis of (Aza)indolines via Dehydrogenative [3+2] Annulation: Application to Total Synthesis of (±)-Hinckdentine A
Hou, Zhong-Wei,Yan, Hong,Song, Jin-Shuai,Xu, Hai-Chao
, p. 909 - 915 (2018/08/11)
An electrochemical synthesis of functionalized (aza)indolines through dehydrogenative [3+2] annulation of arylamines with tethered alkenes has been developed. Previous reported syntheses through similar inter- and intramolecular annulation reactions requi
SUBSTITUTED PHENYL CYCLOALKYL PYRROLIDINE (PIPERIDINE) SPIROLACTAMS AND AMIDES, PREPARATION AND THERAPEUTIC USE THEREOF
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Page/Page column 46-47, (2011/12/02)
The present invention discloses and claims respectively a series of substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides of formula (I) (Ia) and formula (Ib) as described herein. More specifically, the compounds of this invention
PYRAZINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS
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Page/Page column 147, (2010/06/15)
Pyrazine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
AMINOPYRIDINE AND CARBOXYPYRIDINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS
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Page/Page column 128-129, (2010/07/04)
Pyridine and pyrimidine compounds: or a pharmaceutically acceptable salt thereof, wherein m, n, R1, R2, R3, R4, R5, R6, R7, X1, X2, X3, X4, X5, X6, X7, X8, and Y are as defined in the specification; or a pharmaceutically acceptable salt thereof, wherein ring A, m, n, y, R2, R3, R4, R5, R6, R7, R8, R9, X1, X2, and ring A are as defined in the specification; and or a pharmaceutically acceptable salt thereof, wherein m, n, y, R2, R3, R4, R5, R6, R7, R9, X1, X2, and ring A are as defined in the specification; compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
COMPOUNDS AND METHODS FOR MODULATING FXR
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Page/Page column 32, (2009/03/07)
Compounds of formula (I): formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and diseases related to dyslipidemia.
4-CARBOX PYRAZOLE DERIVATES USEFUL AS ANTI-VIRAL AGENTS
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Page/Page column 64, (2010/02/14)
Novel antiviral compounds of Formula (I) : wherein: A represents hydroxy; R1 represents aryl, heteroaryl bonded through a ring carbon atom, or heterocyclyl bonded through a ring carbon atom, C1-6alkyl or -C5-9cycloalkyl, each of which may be optionally su
Enantioselective Diels-Alder cycloadditions with (SS)-2-(p- tolylsulfinyl)-1,4-naphthoquinone: Efficient kinetic resolution of chiral racemic vinylcyclohexenes
Carreno, M. Carmen,Urbano, Antonio,Di Vitta, Claudio
, p. 8320 - 8330 (2007/10/03)
Chiral racemic vinylcyclohexenes 1a-m, bearing allylic and nonallylic oxygenated substituents on the cyclohexene ring, were submitted to Diels- Alder reactions with enantiomerically pure (SS)-(2-p-tolylsulfinyl)-1,4- naphthoquinone. The tandem cycloadditi
