Technology Process of 1-(2-hydroxyethyl)-cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]amide
There total 10 articles about 1-(2-hydroxyethyl)-cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]amide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-(4,5-difluoro-6-(2-fluoro-4-iodophenylamino)benzofuran-7-yl)-1-(2-oxoethyl)cyclopropane-1-sulfonamide;
With
sodium tetrahydroborate;
In
tetrahydrofuran;
at 0 ℃;
With
methanol;
In
tetrahydrofuran;
at 0 - 10 ℃;
for 0.666667h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h / -78 °C
1.2: 1 h / 20 °C
2.1: sodium hydride / tetrahydrofuran / 0 - 40 °C
2.2: 0 - 20 °C
3.1: acetic acid
3.2: 0 - 40 °C
4.1: hydrogenchloride / water; tetrahydrofuran
4.2: 0 - 40 °C
5.1: dichloromethane / 20 - 40 °C
6.1: triethylamine / dichloromethane / 0 °C
6.2: 12 h / 20 - 40 °C
7.1: potassium trimethylsilonate / tetrahydrofuran / 0 - 40 °C
8.1: 2,6-dimethylpyridine; sodium periodate / 1,4-dioxane
8.2: 20 - 40 °C
9.1: sodium tetrahydroborate / tetrahydrofuran / 0 °C
9.2: 0.67 h / 0 - 10 °C
With
2,6-dimethylpyridine; hydrogenchloride; sodium tetrahydroborate; sodium periodate; potassium trimethylsilonate; sodium hydride; acetic acid; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h / -78 °C
1.2: 1 h / 20 °C
2.1: sodium hydride / tetrahydrofuran / 0 - 40 °C
2.2: 0 - 20 °C
3.1: acetic acid
3.2: 0 - 40 °C
4.1: hydrogenchloride / water; tetrahydrofuran
4.2: 0 - 40 °C
5.1: dichloromethane / 20 - 40 °C
6.1: triethylamine / dichloromethane / 0 °C
6.2: 12 h / 20 - 40 °C
7.1: potassium trimethylsilonate / tetrahydrofuran / 0 - 40 °C
8.1: 2,6-dimethylpyridine; sodium periodate / 1,4-dioxane
8.2: 20 - 40 °C
9.1: sodium tetrahydroborate / tetrahydrofuran / 0 °C
9.2: 0.67 h / 0 - 10 °C
With
2,6-dimethylpyridine; hydrogenchloride; sodium tetrahydroborate; sodium periodate; potassium trimethylsilonate; sodium hydride; acetic acid; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water;