(3R,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-hydroxymethylhexahydropyridazine

Base Information

Chemical Name:(3R,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-hydroxymethylhexahydropyridazine
CAS No.:449146-84-3
Molecular Formula:C₂₃H₂₈N₂O₅
Molecular Weight:412.486
Hs Code.:

Synonyms:(3R,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-hydroxymethylhexahydropyridazine

Suppliers and Price of (3R,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-hydroxymethylhexahydropyridazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-hydroxymethylhexahydropyridazine

Chemical Property:

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Technology Process of (3R,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-hydroxymethylhexahydropyridazine

There total 1 articles about (3R,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-hydroxymethylhexahydropyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 506-96-7
Acetyl bromide

: 261761-97-1
(3R,4R,5R)-1-N-Acetyl-3',4,5-tri-O-benzyl-4,5-dihydroxy-3-hydroxymethylhexahydropyridazine

: 449146-84-3
(3R,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-hydroxymethylhexahydropyridazine

: 1-((4R,5R,6R)-2-Acetyl-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyridazin-1-yl)-ethanone

Guidance literature:: Acetyl bromide; (3R,4R,5R)-1-N-Acetyl-3',4,5-tri-O-benzyl-4,5-dihydroxy-3-hydroxymethylhexahydropyridazine; at 25 ℃; for 7h;

With sodium methylate; In methanol; for 1h; Further stages.;
DOI:10.1039/b200884j

Reference yield: 66.0%

: 449146-84-3
(3R,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-hydroxymethylhexahydropyridazine

: 449146-86-5
(3S,4R,5R)-1,2-diacetyl-4,5-dibenzyloxyhexahydropyridazine-3-carboxylic acid

Guidance literature:: With chromium(VI) oxide; sulfuric acid; In acetone; at 0 ℃;
DOI:10.1039/b200884j

Reference yield:

: 449146-84-3
(3R,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-hydroxymethylhexahydropyridazine

: 449146-92-3
(3R,4R,5R)-1,2-diacetyl-4,5-dibenzyloxy-3-methylhexahydropyridazine

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / methanesulfonyl chloride; CsCl; pyridine / 4 h / 80 °C

2: 66 percent / n-Bu₃SnH; AIBN / toluene / 1.5 h / 110 °C

With pyridine; 2,2'-azobis(isobutyronitrile); cesium chloride; tri-n-butyl-tin hydride; methanesulfonyl chloride; In toluene;
DOI:10.1039/b200884j