(R)-(+)-1-phenylbut-3-enyl acrylate

Base Information

Chemical Name:(R)-(+)-1-phenylbut-3-enyl acrylate
CAS No.:765940-97-4
Molecular Formula:C₁₃H₁₄O₂
Molecular Weight:202.253
Hs Code.:

Synonyms:(R)-(+)-1-phenylbut-3-enyl acrylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(+)-1-phenylbut-3-enyl acrylate

Chemical Property:

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Technology Process of (R)-(+)-1-phenylbut-3-enyl acrylate

There total 6 articles about (R)-(+)-1-phenylbut-3-enyl acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 85551-57-1,936-58-3
(R)-1-Phenylbut-3-en-1-ol

: 814-68-6,25189-84-8
acryloyl chloride

: 765940-97-4
(R)-(+)-1-phenylbut-3-enyl acrylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/chem.201301980

Reference yield:

: 80735-94-0,936-58-3
1-Phenyl-3-buten-1-ol

: 765940-97-4
(R)-(+)-1-phenylbut-3-enyl acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: dicarbonyl(chloro)(η⁵-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; Candida antarctica lipase B; sodium carbonate / tetrahydrofuran; toluene / 12 h / 70 °C / Schlenk technique; Inert atmosphere; Resolution of racemate; Enzymatic reaction

2: dicarbonyl(chloro)(η⁵-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate / tetrahydrofuran; toluene / 2 h / 70 °C

3: dmap; triethylamine / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

With dmap; Candida antarctica lipase B; dicarbonyl(chloro)(η⁵-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; sodium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/chem.201301980

Reference yield:

: 100-52-7
benzaldehyde

: 765940-97-4
(R)-(+)-1-phenylbut-3-enyl acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 2 h / 0 - 20 °C

2: dicarbonyl(chloro)(η⁵-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; Candida antarctica lipase B; sodium carbonate / tetrahydrofuran; toluene / 12 h / 70 °C / Schlenk technique; Inert atmosphere; Resolution of racemate; Enzymatic reaction

3: dicarbonyl(chloro)(η⁵-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate / tetrahydrofuran; toluene / 2 h / 70 °C

4: dmap; triethylamine / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

With dmap; Candida antarctica lipase B; dicarbonyl(chloro)(η⁵-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; sodium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/chem.201301980