4-Phenoxybenzhydrazide

Base Information

• Chemical Name: 4-Phenoxybenzhydrazide
• CAS No.: 143667-36-1
• Molecular Formula: C13H12 N2 O2
• Molecular Weight: 228.25
• Hs Code.: 2928000090
• European Community (EC) Number: 673-736-9
• DSSTox Substance ID: DTXSID70375116
• Wikidata: Q82163651
• Mol file: 143667-36-1.mol

Synonyms:4-Phenoxybenzhydrazide;4-phenoxybenzohydrazide;143667-36-1;SCHEMBL2835202;1-phenoxybenzene-4-carbohydrazide;DTXSID70375116;LRBASDKESQRLCX-UHFFFAOYSA-N;MFCD00153894;STK331011;AKOS015855150;SB86449;BS-42396;CS-0360495;FT-0682117;Z58981836;ETHYL3-AMINO-4-(ISOPROPYLSULFONYL)-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLATE

Chemical Property of 4-Phenoxybenzhydrazide

Chemical Property:

• Melting Point: 125-127°C
• Refractive Index: 1.612
• Boiling Point: °Cat760mmHg
• PKA: 12.40±0.10(Predicted)
• Flash Point: °C
• PSA: 64.35000
• Density: 1.217g/cm³
• LogP: 3.17360
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 228.089877630
• Heavy Atom Count: 17
• Complexity: 244

Purity/Quality:

98%min ^*data from raw suppliers

4-Phenoxybenzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OC2=CC=C(C=C2)C(=O)NN

Technology Process of 4-Phenoxybenzhydrazide

There total 3 articles about 4-Phenoxybenzhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl 4-phenoxybenzoate (21218-94-0) → 4-phenoxy-benzoic acid hydrazide (143667-36-1)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

DOI:10.3390/molecules25143125

Reference yield:

4-phenoxybenzoic acid ethyl ester (31994-68-0) → 4-phenoxy-benzoic acid hydrazide (143667-36-1)

Guidance literature:

With ethanol; hydrazine hydrate;

Reference yield:

4-Phenoxybenzoic acid (2215-77-2) → 4-phenoxy-benzoic acid hydrazide (143667-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 8 h / Reflux

2: hydrazine hydrate / ethanol / Reflux

With sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.3390/molecules25143125

upstream raw materials:

4-phenoxybenzoic acid ethyl ester

methyl 4-phenoxybenzoate

4-Phenoxybenzoic acid

Downstream raw materials:

[(4-Phenoxy-benzoyl)-hydrazono]-acetic acid

(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-{2-[(4-phenoxy-benzoyl)-hydrazono]-acetylamino}-2-phenyl-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

C₁₄H₁₀N₂O₂S

2-(4-phenoxybenzoyl)-N-phenylhydrazine-1-carbothioamide