(S)-1-(4-(4-(3-methylmorpholin-4-yl)-6-(2-(methylsulfonyl)phenyl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-3-yl)urea

Base Information

Chemical Name:(S)-1-(4-(4-(3-methylmorpholin-4-yl)-6-(2-(methylsulfonyl)phenyl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-3-yl)urea
CAS No.:1428531-95-6
Molecular Formula:C₂₇H₂₇N₇O₄S
Molecular Weight:545.622
Hs Code.:

Synonyms:(S)-1-(4-(4-(3-methylmorpholin-4-yl)-6-(2-(methylsulfonyl)phenyl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-3-yl)urea

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Chemical Property of (S)-1-(4-(4-(3-methylmorpholin-4-yl)-6-(2-(methylsulfonyl)phenyl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-3-yl)urea

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Technology Process of (S)-1-(4-(4-(3-methylmorpholin-4-yl)-6-(2-(methylsulfonyl)phenyl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-3-yl)urea

There total 5 articles about (S)-1-(4-(4-(3-methylmorpholin-4-yl)-6-(2-(methylsulfonyl)phenyl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-3-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 462-08-8
pyridin-3-ylamine

: 32315-10-9
bis(trichloromethyl) carbonate

: 1428532-51-7
(S)-4-(4-(3-methylmorpholin-4-yl)-6-(2-(methylsulfonyl)phenyl)-1,3,5-triazin-2-yl)aniline hydrochloride

: 1428531-95-6
(S)-1-(4-(4-(3-methylmorpholin-4-yl)-6-(2-(methylsulfonyl)phenyl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-3-yl)urea

Guidance literature:: bis(trichloromethyl) carbonate; (S)-4-(4-(3-methylmorpholin-4-yl)-6-(2-(methylsulfonyl)phenyl)-1,3,5-triazin-2-yl)aniline hydrochloride; With pyridine; In tetrahydrofuran; for 0.0833333h; Cooling with ice;

pyridin-3-ylamine; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

: 1428532-48-2
(S)-4-(4-chloro-6-(2-(methylsulfonyl)phenyl)-1,3,5-triazin-2-yl)-3-methylmorpholine

: 1428531-95-6
(S)-1-(4-(4-(3-methylmorpholin-4-yl)-6-(2-(methylsulfonyl)phenyl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-3-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 0.67 h / 120 °C / Microwave irradiation

2.1: hydrogenchloride; methanol / 1,4-dioxane / 24 h

3.1: pyridine / tetrahydrofuran / Cooling with ice

3.2: 1 h / 0 °C

With pyridine; hydrogenchloride; methanol; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: C₂₆H₃₁N₅O₅S

: 1428531-95-6
(S)-1-(4-(4-(3-methylmorpholin-4-yl)-6-(2-(methylsulfonyl)phenyl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-3-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; methanol / 1,4-dioxane / 24 h

2.1: pyridine / tetrahydrofuran / Cooling with ice

2.2: 1 h / 0 °C

With pyridine; hydrogenchloride; methanol; In tetrahydrofuran; 1,4-dioxane;