dimethyl [4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene]-malonate

Base Information

• Chemical Name: dimethyl [4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene]-malonate
• CAS No.: 209530-90-5
• Molecular Formula: C₂₄H₂₃NO₆
• Molecular Weight: 421.45
• Mol file: 209530-90-5.mol

Synonyms:dimethyl [4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene]-malonate

Chemical Property of dimethyl [4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene]-malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl [4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene]-malonate

There total 1 articles about dimethyl [4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene]-malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzaldehyde (103788-59-6) + malonic acid dimethyl ester (108-59-8) → dimethyl [4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene]-malonate (209530-90-5)

Guidance literature:

With piperdinium acetate; In toluene; for 4h; Heating;

DOI:10.1021/jm970771m

Reference yield: 85.0%

dimethyl [4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene]-malonate (209530-90-5) → dimethyl 2-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyl]malonate (170861-71-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; Ambient temperature;

DOI:10.1021/jm970771m

Reference yield:

dimethyl [4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene]-malonate (209530-90-5) → 2-Carbamoyl-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propionic acid

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / H₂ / 5percent Pd/C / methanol; dioxane / Ambient temperature

2: 80 percent / aq. hydroxylamine, Na₂CO₃ / tetrahydrofuran; methanol / 3 h / 60 °C

3: 83 percent / H₂ / 5percent Pd/C / tetrahydrofuran; methanol / 2206.5 Torr / Ambient temperature

With hydrogen; hydroxylamine; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1021/jm970771m

upstream raw materials:

4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzaldehyde

malonic acid dimethyl ester

Downstream raw materials:

dimethyl 2-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyl]malonate

reglitazar

methyl 2-carbamoyl-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propionate

2-methoxycarbonyl-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propionic acid