2-(cyclohexylcarbonyl)-10-(3-hydroxypropoxy)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

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Chemical Name:2-(cyclohexylcarbonyl)-10-(3-hydroxypropoxy)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
CAS No.:1621707-06-9
Molecular Formula:C₂₂H₃₀N₂O₄
Molecular Weight:386.491
Hs Code.:

Synonyms:2-(cyclohexylcarbonyl)-10-(3-hydroxypropoxy)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

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Chemical Property of 2-(cyclohexylcarbonyl)-10-(3-hydroxypropoxy)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

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Technology Process of 2-(cyclohexylcarbonyl)-10-(3-hydroxypropoxy)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

There total 5 articles about 2-(cyclohexylcarbonyl)-10-(3-hydroxypropoxy)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1352568-78-5
2-(cyclohexylcarbonyl)-10-hydroxy-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

: 627-18-9
1-bromo-3-propanol

: 1621707-06-9
2-(cyclohexylcarbonyl)-10-(3-hydroxypropoxy)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

Guidance literature:: With potassium carbonate; In acetonitrile; for 24h; Reflux;
DOI:10.1016/j.ejmech.2014.07.007

Reference yield:

: 55-81-2
4-Methoxyphenethylamine

: 1621707-06-9
2-(cyclohexylcarbonyl)-10-(3-hydroxypropoxy)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water; dichloromethane / 4 h / Reflux

2.1: methanol / 48 h / 20 °C

3.1: methanesulfonic acid / 5 h / 0 - 70 °C

4.1: boron tribromide / dichloromethane / 3 h / 20 °C

4.2: 1 h / 0 °C

5.1: potassium carbonate / acetonitrile / 24 h / Reflux

With methanesulfonic acid; N-benzyl-N,N,N-triethylammonium chloride; boron tribromide; potassium carbonate; sodium hydroxide; In methanol; dichloromethane; water; acetonitrile; 2.1: |Ugi Condensation / 3.1: |Pictet-Spengler Synthesis;
DOI:10.1016/j.ejmech.2014.07.007

Reference yield:

: 1373257-26-1
2-(cyclohexylcarbonyl)-10-methoxy-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

: 1621707-06-9
2-(cyclohexylcarbonyl)-10-(3-hydroxypropoxy)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron tribromide / dichloromethane / 3 h / 20 °C

1.2: 1 h / 0 °C

2.1: potassium carbonate / acetonitrile / 24 h / Reflux

With boron tribromide; potassium carbonate; In dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2014.07.007