2-(cyclohexylcarbonyl)-10-methoxy-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

Base Information

Chemical Name:2-(cyclohexylcarbonyl)-10-methoxy-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
CAS No.:1373257-26-1
Molecular Formula:C₂₀H₂₆N₂O₃
Molecular Weight:342.438
Hs Code.:

Synonyms:2-(cyclohexylcarbonyl)-10-methoxy-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

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Chemical Property of 2-(cyclohexylcarbonyl)-10-methoxy-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

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Technology Process of 2-(cyclohexylcarbonyl)-10-methoxy-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

There total 5 articles about 2-(cyclohexylcarbonyl)-10-methoxy-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1352568-78-5
2-(cyclohexylcarbonyl)-10-hydroxy-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

: 74-88-4
methyl iodide

: 1373257-26-1
2-(cyclohexylcarbonyl)-10-methoxy-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1111/cbdd.12153

Reference yield: 40.0%

: N-(2,2-dimethoxyethyl)-N-(2-oxo-2-(2-(4-methoxy)phenethylamino)ethyl)cyclohexane carboxamide

: 1373257-26-1
2-(cyclohexylcarbonyl)-10-methoxy-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

Guidance literature:: With methanesulfonic acid; at 0 - 70 ℃; for 5h;
DOI:10.1016/j.ejmech.2014.07.007

Reference yield:

: 55-81-2
4-Methoxyphenethylamine

: 1373257-26-1
2-(cyclohexylcarbonyl)-10-methoxy-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water; dichloromethane / 4 h / Reflux

2: methanol / 48 h / 20 °C

3: methanesulfonic acid / 5 h / 0 - 70 °C

With methanesulfonic acid; N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; In methanol; dichloromethane; water; 2: |Ugi Condensation / 3: |Pictet-Spengler Synthesis;
DOI:10.1016/j.ejmech.2014.07.007