2,2-difluoro-1-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(6-(methylsulfonylmethyl)pyridin-3-yl)phenyl)oxazolidin-3-yl)ethanone

Base Information

Chemical Name:2,2-difluoro-1-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(6-(methylsulfonylmethyl)pyridin-3-yl)phenyl)oxazolidin-3-yl)ethanone
CAS No.:1582262-86-9
Molecular Formula:C₂₁H₂₃F₃N₂O₄S
Molecular Weight:456.486
Hs Code.:

Synonyms:2,2-difluoro-1-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(6-(methylsulfonylmethyl)pyridin-3-yl)phenyl)oxazolidin-3-yl)ethanone

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Chemical Property of 2,2-difluoro-1-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(6-(methylsulfonylmethyl)pyridin-3-yl)phenyl)oxazolidin-3-yl)ethanone

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Technology Process of 2,2-difluoro-1-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(6-(methylsulfonylmethyl)pyridin-3-yl)phenyl)oxazolidin-3-yl)ethanone

There total 5 articles about 2,2-difluoro-1-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(6-(methylsulfonylmethyl)pyridin-3-yl)phenyl)oxazolidin-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352754-05-2
5-bromo-2-[(methylsulfonyl)methyl]pyridine

: 1454906-87-6
2,2-difluoro-1-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)oxazolidin-3-yl)ethanone

: 1582262-86-9
2,2-difluoro-1-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(6-(methylsulfonylmethyl)pyridin-3-yl)phenyl)oxazolidin-3-yl)ethanone

Guidance literature:: With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium hydrogencarbonate; In isopropyl alcohol; toluene; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 88139-91-7
(5-bromopyridin-2-yl)methanol

: 1582262-86-9
2,2-difluoro-1-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(6-(methylsulfonylmethyl)pyridin-3-yl)phenyl)oxazolidin-3-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 1 h

1.2: 16 h / 20 °C

2.1: sodium hydrogencarbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / toluene; isopropyl alcohol / 0.5 h / 120 °C / Microwave irradiation

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium hydrogencarbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; isopropyl alcohol; toluene;

Reference yield:

: 1454906-86-5
2,2-difluoro-1-((4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidin-3-yl)ethanone

: 1582262-86-9
2,2-difluoro-1-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(6-(methylsulfonylmethyl)pyridin-3-yl)phenyl)oxazolidin-3-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 22 h / 90 °C / Inert atmosphere

2: sodium hydrogencarbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / toluene; isopropyl alcohol / 0.5 h / 120 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; sodium hydrogencarbonate; In 1,4-dioxane; isopropyl alcohol; toluene;