N-((1R,2S)-1-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide

Base Information

Chemical Name:N-((1R,2S)-1-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide
CAS No.:1582261-95-7
Molecular Formula:C₁₈H₁₇F₅N₂O₄S
Molecular Weight:452.402
Hs Code.:

Synonyms:N-((1R,2S)-1-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide

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Chemical Property of N-((1R,2S)-1-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide

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Technology Process of N-((1R,2S)-1-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide

There total 8 articles about N-((1R,2S)-1-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1582262-87-0
1-((4S,5R)-5-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-4-(fluoromethyl)-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

: 1582261-95-7
N-((1R,2S)-1-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 5 ℃; for 0.5h;

Reference yield:

: 927689-70-1
(1R,2S)-2-amino-3-fluoro-1-(4-iodophenyl)propan-1-ol

: 1582261-95-7
N-((1R,2S)-1-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 22 h / 90 °C / Inert atmosphere

4.1: sodium hydrogencarbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / toluene; isopropyl alcohol / 0.5 h / 120 °C / Microwave irradiation

5.1: potassium hexamethylsilazane / tetrahydrofuran / 0.67 h / -70 °C

5.2: 0.5 h / -70 °C

5.3: -70 - 20 °C

6.1: hydrogenchloride; water / 1,4-dioxane / 0.5 h / 5 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; water; potassium acetate; potassium hexamethylsilazane; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; isopropyl alcohol; toluene;

Reference yield:

: 88139-91-7
(5-bromopyridin-2-yl)methanol

: 1582261-95-7
N-((1R,2S)-1-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 1 h

1.2: 16 h / 20 °C

2.1: sodium hydrogencarbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / toluene; isopropyl alcohol / 0.5 h / 120 °C / Microwave irradiation

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.67 h / -70 °C

3.2: 0.5 h / -70 °C

3.3: -70 - 20 °C

4.1: hydrogenchloride; water / 1,4-dioxane / 0.5 h / 5 °C

With hydrogenchloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; water; potassium hexamethylsilazane; sodium hydrogencarbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; isopropyl alcohol; toluene;