1-((4S,5R)-5-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-4-(fluoromethyl)-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

Base Information

Chemical Name:1-((4S,5R)-5-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-4-(fluoromethyl)-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone
CAS No.:1582262-87-0
Molecular Formula:C₂₁H₂₁F₅N₂O₄S
Molecular Weight:492.467
Hs Code.:

Synonyms:1-((4S,5R)-5-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-4-(fluoromethyl)-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

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Chemical Property of 1-((4S,5R)-5-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-4-(fluoromethyl)-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

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Technology Process of 1-((4S,5R)-5-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-4-(fluoromethyl)-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

There total 6 articles about 1-((4S,5R)-5-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-4-(fluoromethyl)-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1582262-86-9
2,2-difluoro-1-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(6-(methylsulfonylmethyl)pyridin-3-yl)phenyl)oxazolidin-3-yl)ethanone

: 1582262-87-0
1-((4S,5R)-5-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-4-(fluoromethyl)-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

Guidance literature:: 2,2-difluoro-1-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(6-(methylsulfonylmethyl)pyridin-3-yl)phenyl)oxazolidin-3-yl)ethanone; With potassium hexamethylsilazane; In tetrahydrofuran; at -70 ℃; for 0.666667h;

With manganese(II) bromide; In tetrahydrofuran; at -70 ℃; for 0.5h;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at -70 - 20 ℃;

Reference yield:

: 927689-70-1
(1R,2S)-2-amino-3-fluoro-1-(4-iodophenyl)propan-1-ol

: 1582262-87-0
1-((4S,5R)-5-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-4-(fluoromethyl)-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 22 h / 90 °C / Inert atmosphere

4.1: sodium hydrogencarbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / toluene; isopropyl alcohol / 0.5 h / 120 °C / Microwave irradiation

5.1: potassium hexamethylsilazane / tetrahydrofuran / 0.67 h / -70 °C

5.2: 0.5 h / -70 °C

5.3: -70 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; potassium hexamethylsilazane; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; isopropyl alcohol; toluene;

Reference yield:

: 88139-91-7
(5-bromopyridin-2-yl)methanol

: 1582262-87-0
1-((4S,5R)-5-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-4-(fluoromethyl)-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 1 h

1.2: 16 h / 20 °C

2.1: sodium hydrogencarbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / toluene; isopropyl alcohol / 0.5 h / 120 °C / Microwave irradiation

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.67 h / -70 °C

3.2: 0.5 h / -70 °C

3.3: -70 - 20 °C

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium hexamethylsilazane; sodium hydrogencarbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; isopropyl alcohol; toluene;