{(R)-3-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentanoylamino)-3-methyl-butyrylamino]-dodecanoylamino}-acetic acid

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Chemical Name:{(R)-3-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentanoylamino)-3-methyl-butyrylamino]-dodecanoylamino}-acetic acid
CAS No.:172941-99-0
Molecular Formula:C₃₇H₆₁N₅O₉
Molecular Weight:719.919
Hs Code.:

Synonyms:{(R)-3-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentanoylamino)-3-methyl-butyrylamino]-dodecanoylamino}-acetic acid

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Chemical Property of {(R)-3-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentanoylamino)-3-methyl-butyrylamino]-dodecanoylamino}-acetic acid

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Technology Process of {(R)-3-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentanoylamino)-3-methyl-butyrylamino]-dodecanoylamino}-acetic acid

There total 6 articles about {(R)-3-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentanoylamino)-3-methyl-butyrylamino]-dodecanoylamino}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 172941-98-9
N²-tert-butoxycarbonyl-N⁵-benzyloxycarbonylornithyl-valyl-((R)-3-nonyl-β-alanyl)-glycine ethyl ester

: 172941-99-0
{(R)-3-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentanoylamino)-3-methyl-butyrylamino]-dodecanoylamino}-acetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1021/ol005631c

Reference yield:

: 2480-93-5
Boc-Orn(Z)-OH

: 172941-99-0
{(R)-3-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentanoylamino)-3-methyl-butyrylamino]-dodecanoylamino}-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: WSCD*HCl; 1-hydroxybenzotriazole hydrate; triethylamine / tetrahydrofuran

2: 95 percent / LiOH / tetrahydrofuran; methanol; H₂O

With lithium hydroxide; WSCD*HCl; 1-hydroxybenzotriazol-hydrate; triethylamine; In tetrahydrofuran; methanol; water; 1: Condensation / 2: Hydrolysis;
DOI:10.1021/ol005631c

Reference yield:

: 172941-77-4
Boc-L-Val-3(R)-aminododecanoic acid methyl ester

: 172941-99-0
{(R)-3-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentanoylamino)-3-methyl-butyrylamino]-dodecanoylamino}-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: LiOH / tetrahydrofuran; methanol; H₂O

2: WSCD*HCl; 1-hydroxybenzotriazole hydrate; triethylamine / tetrahydrofuran; dimethylformamide

3: trifluoroacetic acid / CH₂Cl₂

4: WSCD*HCl; 1-hydroxybenzotriazole hydrate; triethylamine / tetrahydrofuran

5: 95 percent / LiOH / tetrahydrofuran; methanol; H₂O

With lithium hydroxide; WSCD*HCl; 1-hydroxybenzotriazol-hydrate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Hydrolysis / 2: Condensation / 3: Hydrolysis / 4: Condensation / 5: Hydrolysis;
DOI:10.1021/ol005631c