Acetic acid (2R,3R,4S,5R,6S)-3-acetoxy-2-acetoxymethyl-6-[(S)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propoxy]-5-benzyloxy-tetrahydro-pyran-4-yl ester

Base Information

Chemical Name:Acetic acid (2R,3R,4S,5R,6S)-3-acetoxy-2-acetoxymethyl-6-[(S)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propoxy]-5-benzyloxy-tetrahydro-pyran-4-yl ester
CAS No.:190779-84-1
Molecular Formula:C₅₁H₅₇N₅O₁₂Si
Molecular Weight:960.125
Hs Code.:

Acetic acid (2R,3R,4S,5R,6S)-3-acetoxy-2-acetoxymethyl-6-[(S)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propoxy]-5-benzyloxy-tetrahydro-pyran-4-yl ester

Synonyms:Acetic acid (2R,3R,4S,5R,6S)-3-acetoxy-2-acetoxymethyl-6-[(S)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propoxy]-5-benzyloxy-tetrahydro-pyran-4-yl ester

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Chemical Property of Acetic acid (2R,3R,4S,5R,6S)-3-acetoxy-2-acetoxymethyl-6-[(S)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propoxy]-5-benzyloxy-tetrahydro-pyran-4-yl ester

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Technology Process of Acetic acid (2R,3R,4S,5R,6S)-3-acetoxy-2-acetoxymethyl-6-[(S)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propoxy]-5-benzyloxy-tetrahydro-pyran-4-yl ester

There total 7 articles about Acetic acid (2R,3R,4S,5R,6S)-3-acetoxy-2-acetoxymethyl-6-[(S)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propoxy]-5-benzyloxy-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 18055-47-5
N-Benzoyl-N,9-bis(trimethylsilyl)adenin

: 190779-75-0
Acetic acid (S)-2-(tert-butyl-diphenyl-silanyloxy)-1-((2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-3-benzyloxy-tetrahydro-pyran-2-yloxymethyl)-ethoxymethyl ester

: 190779-84-1
Acetic acid (2R,3R,4S,5R,6S)-3-acetoxy-2-acetoxymethyl-6-[(S)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propoxy]-5-benzyloxy-tetrahydro-pyran-4-yl ester

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; for 16h; Heating;
DOI:10.1016/S0040-4020(97)00309-8

Reference yield:

: 4005-49-6
N-benzoyladenine

: 190779-84-1
Acetic acid (2R,3R,4S,5R,6S)-3-acetoxy-2-acetoxymethyl-6-[(S)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propoxy]-5-benzyloxy-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 6 h / Heating

2: 52 percent / TMSOTf / 1,2-dichloro-ethane / 16 h / Heating

With pyridine; trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane;
DOI:10.1016/S0040-4020(97)00309-8

Reference yield:

: 190779-52-3
ethyl-3,4,6-tri-O-acetyl-2-O-benzyl-1-thio-D-glucopyranoside

: 190779-84-1
Acetic acid (2R,3R,4S,5R,6S)-3-acetoxy-2-acetoxymethyl-6-[(S)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propoxy]-5-benzyloxy-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 72 percent / NIS, TfOH / diethyl ether / 2 h / Ambient temperature

2: 87 percent / CAN / acetonitrile; H₂O / 0.5 h / Ambient temperature

3: 62 percent / DMAP / pyridine / 48 h / 60 °C

4: 63 percent / 2,6-lutidine, BPO / acetonitrile / 0.5 h / Ambient temperature

5: 85 percent / NIS / 1,2-dichloro-ethane; tetrahydrofuran / 0.08 h / 0 °C

6: 52 percent / TMSOTf / 1,2-dichloro-ethane / 16 h / Heating

With 2,6-dimethylpyridine; dmap; N-iodo-succinimide; ammonium cerium(IV) nitrate; trifluorormethanesulfonic acid; trimethylsilyl trifluoromethanesulfonate; dibenzoyl peroxide; In tetrahydrofuran; pyridine; diethyl ether; water; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1016/S0040-4020(97)00309-8