5-[2-bromo-4-(1-{2-[4-(N-hydroxycarbamimidoyl)-phenylcarbamoyl]-acetylamino}-ethyl)-phenoxy]-nicotinic acid hydrochloride

Base Information

Chemical Name:5-[2-bromo-4-(1-{2-[4-(N-hydroxycarbamimidoyl)-phenylcarbamoyl]-acetylamino}-ethyl)-phenoxy]-nicotinic acid hydrochloride
CAS No.:1100767-40-5
Molecular Formula:C₂₄H₂₂BrN₅O₆*ClH
Molecular Weight:592.834
Hs Code.:

Synonyms:5-[2-bromo-4-(1-{2-[4-(N-hydroxycarbamimidoyl)-phenylcarbamoyl]-acetylamino}-ethyl)-phenoxy]-nicotinic acid hydrochloride

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Chemical Property of 5-[2-bromo-4-(1-{2-[4-(N-hydroxycarbamimidoyl)-phenylcarbamoyl]-acetylamino}-ethyl)-phenoxy]-nicotinic acid hydrochloride

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Technology Process of 5-[2-bromo-4-(1-{2-[4-(N-hydroxycarbamimidoyl)-phenylcarbamoyl]-acetylamino}-ethyl)-phenoxy]-nicotinic acid hydrochloride

There total 9 articles about 5-[2-bromo-4-(1-{2-[4-(N-hydroxycarbamimidoyl)-phenylcarbamoyl]-acetylamino}-ethyl)-phenoxy]-nicotinic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1100767-38-1
methyl-5-[2-bromo-4-(1-{2-[4-(N-hydroxycarbamimidoyl)-phenylcarbamoyl]-acetylamino}-ethyl)-phenoxy]-nicotinate

: 1100767-40-5
5-[2-bromo-4-(1-{2-[4-(N-hydroxycarbamimidoyl)-phenylcarbamoyl]-acetylamino}-ethyl)-phenoxy]-nicotinic acid hydrochloride

Guidance literature:: methyl-5-[2-bromo-4-(1-{2-[4-(N-hydroxycarbamimidoyl)-phenylcarbamoyl]-acetylamino}-ethyl)-phenoxy]-nicotinate; With lithium hydroxide; water; In methanol; at 20 - 50 ℃;

With hydrogenchloride; In methanol; water; pH=6;

Reference yield:

: 1100767-21-2
2-[4-cyano-phenylcarbamoyl]-acetic acid

: 1100767-40-5
5-[2-bromo-4-(1-{2-[4-(N-hydroxycarbamimidoyl)-phenylcarbamoyl]-acetylamino}-ethyl)-phenoxy]-nicotinic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C

2.1: hydroxylamine hydrochloride; triethylamine / isopropyl alcohol / 4 h / 70 °C

3.1: lithium hydroxide; water / methanol / 20 - 50 °C

3.2: pH 6

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydroxylamine hydrochloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 113117-17-2
ethyl 3-[(4-cyanophenyl)amino]-3-oxopropanoate

: 1100767-40-5
5-[2-bromo-4-(1-{2-[4-(N-hydroxycarbamimidoyl)-phenylcarbamoyl]-acetylamino}-ethyl)-phenoxy]-nicotinic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide; water / methanol / 20 °C

2.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C

3.1: hydroxylamine hydrochloride; triethylamine / isopropyl alcohol / 4 h / 70 °C

4.1: lithium hydroxide; water / methanol / 20 - 50 °C

4.2: pH 6

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydroxylamine hydrochloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;