2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetic acid

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Chemical Name:2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetic acid
CAS No.:1443114-18-8
Molecular Formula:C₁₉H₁₂F₂N₄O₃S
Molecular Weight:414.392
Hs Code.:

Synonyms:2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetic acid

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Chemical Property of 2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetic acid

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Technology Process of 2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetic acid

There total 2 articles about 2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1443114-17-7
ethyl 2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetate

: 1443114-18-8
2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetic acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ml400166b

Reference yield:

: 7187-47-5
4-(1H-benzo[d]imidazol-2-yl)-1,3-thiazol-2-amine

: 1443114-18-8
2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

3.1: sodium hydroxide / methanol; water / 12 h / 20 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ml400166b