ethyl 2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetate

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Chemical Name:ethyl 2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetate
CAS No.:1443114-17-7
Molecular Formula:C₂₁H₁₆F₂N₄O₃S
Molecular Weight:442.446
Hs Code.:

Synonyms:ethyl 2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetate

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Chemical Property of ethyl 2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetate

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Technology Process of ethyl 2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetate

There total 2 articles about ethyl 2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1443114-15-5
N-(4-(1H-benzo[d]imidazol-2-yl)thiazol-2-yl)-2,6-difluorobenzamide

: 105-36-2
ethyl bromoacetate

: 1443114-17-7
ethyl 2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ml400166b

Reference yield:

: 7187-47-5
4-(1H-benzo[d]imidazol-2-yl)-1,3-thiazol-2-amine

: 1443114-17-7
ethyl 2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ml400166b