Technology Process of 3-methyl-1-phenyl-1H-indazol-6-ylamine hydrochloride
There total 6 articles about 3-methyl-1-phenyl-1H-indazol-6-ylamine hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-bromo-3-methyl-1-phenyl-1H-indazole;
With
Benzophenone imine; caesium carbonate;
palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran;
for 16h;
Inert atmosphere;
Reflux;
With
hydrogenchloride;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid / ethanol / 2 h / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 100 °C
3.1: caesium carbonate; Benzophenone imine / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 16 h / Inert atmosphere; Reflux
3.2: 2 h / 20 °C
With
Benzophenone imine; potassium carbonate; caesium carbonate;
palladium diacetate; toluene-4-sulfonic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diisopropyl-carbodiimide / dichloromethane / 4 h / 0 - 20 °C
2.1: magnesium / diethyl ether / 20 °C / Inert atmosphere
2.2: -20 - 20 °C / Inert atmosphere
2.3: 0 °C / Cooling with ice bath
3.1: toluene-4-sulfonic acid / ethanol / 2 h / Reflux
4.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 100 °C
5.1: caesium carbonate; Benzophenone imine / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 16 h / Inert atmosphere; Reflux
5.2: 2 h / 20 °C
With
Benzophenone imine; potassium carbonate; caesium carbonate; magnesium; diisopropyl-carbodiimide;
palladium diacetate; toluene-4-sulfonic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
