C₂₄H₂₀BrNO₄

Base Information

Chemical Name:C₂₄H₂₀BrNO₄
CAS No.:1373403-19-0
Molecular Formula:C₂₄H₂₀BrNO₄
Molecular Weight:466.331
Hs Code.:

C<sub>24</sub>H<sub>20</sub>BrNO<sub>4</sub>

Synonyms:C₂₄H₂₀BrNO₄

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Chemical Property of C₂₄H₂₀BrNO₄

Chemical Property:

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Technology Process of C₂₄H₂₀BrNO₄

There total 12 articles about C₂₄H₂₀BrNO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1373403-18-9
C₁₇H₁₇BrO

: 122-04-3
4-nitro-benzoyl chloride

: 1373403-19-0
C₂₄H₂₀BrNO₄

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol300770w

Reference yield:

: 60710-39-6
3-bromo-p-cresol

: 1373403-19-0
C₂₄H₂₀BrNO₄

Guidance literature:: Multi-step reaction with 10 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 4 h / -78 °C / Inert atmosphere

3.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; toluene / 24 h / 90 °C / Inert atmosphere

4.1: diisobutylaluminium hydride / hexane; dichloromethane / 3 h / -78 - 20 °C / Inert atmosphere

5.1: pyridine; dmap / chloroform / 0 - 20 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

7.1: triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / dichloromethane / 5 h / 20 °C / Inert atmosphere

8.1: methanol; 5%-palladium/activated carbon; hydrogen / 4 h

9.1: bromine / dichloromethane / 0 - 20 °C / Inert atmosphere

10.1: dmap; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; methanol; dmap; potassium phosphate; n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5%-palladium/activated carbon; tetrabutyl ammonium fluoride; hydrogen; bromine; diisobutylaluminium hydride; triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene; 3.1: Suzuki-Miyaura Cross Coupling / 7.1: Friedel Crafts alkylation;
DOI:10.1021/ol300770w

Reference yield:

: (E)-4-(2-Bromo-phenyl)-but-2-enoic acid ethyl ester

: 1373403-19-0
C₂₄H₂₀BrNO₄

Guidance literature:: Multi-step reaction with 8 steps

1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; toluene / 24 h / 90 °C / Inert atmosphere

2: diisobutylaluminium hydride / hexane; dichloromethane / 3 h / -78 - 20 °C / Inert atmosphere

3: pyridine; dmap / chloroform / 0 - 20 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5: (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / methanol; dichloromethane / 16 h / 20 °C / Inert atmosphere

6: methanol; 5%-palladium/activated carbon; hydrogen / 4 h

7: bromine / dichloromethane / 0 - 20 °C / Inert atmosphere

8: dmap; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; methanol; dmap; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5%-palladium/activated carbon; tetrabutyl ammonium fluoride; hydrogen; bromine; diisobutylaluminium hydride; (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane; triethylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; water; toluene; 1: Suzuki-Miyaura Cross Coupling / 5: Friedel Crafts alkylation;
DOI:10.1021/ol300770w