O-(L-N-(benzyloxycarbonyl)-N,O-dimethyltyrosyl)-N-(tert-butoxycarbonyl)-L-serine phenacyl ester

Base Information

Chemical Name:O-(L-N-(benzyloxycarbonyl)-N,O-dimethyltyrosyl)-N-(tert-butoxycarbonyl)-L-serine phenacyl ester
CAS No.:945473-75-6
Molecular Formula:C₃₅H₄₀N₂O₁₀
Molecular Weight:648.71
Hs Code.:

Synonyms:O-(L-N-(benzyloxycarbonyl)-N,O-dimethyltyrosyl)-N-(tert-butoxycarbonyl)-L-serine phenacyl ester

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Chemical Property of O-(L-N-(benzyloxycarbonyl)-N,O-dimethyltyrosyl)-N-(tert-butoxycarbonyl)-L-serine phenacyl ester

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Technology Process of O-(L-N-(benzyloxycarbonyl)-N,O-dimethyltyrosyl)-N-(tert-butoxycarbonyl)-L-serine phenacyl ester

There total 3 articles about O-(L-N-(benzyloxycarbonyl)-N,O-dimethyltyrosyl)-N-(tert-butoxycarbonyl)-L-serine phenacyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 118171-80-5
(2S)-3-[4-(methyloxy)phenyl]-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)propanoic acid

: 120219-31-0
L-N-(tert-butoxycarbonyl)serine phenacyl ester

: 945473-75-6
O-(L-N-(benzyloxycarbonyl)-N,O-dimethyltyrosyl)-N-(tert-butoxycarbonyl)-L-serine phenacyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1021/jo070412r

Reference yield:

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

: 945473-75-6
O-(L-N-(benzyloxycarbonyl)-N,O-dimethyltyrosyl)-N-(tert-butoxycarbonyl)-L-serine phenacyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / triethylamine / ethyl acetate / 48 h / 20 °C

2: 63 percent / 4-(dimethylamino)pyridine; N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 20 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate;
DOI:10.1021/jo070412r

Reference yield:

: 70-11-1
α-bromoacetophenone

: 945473-75-6
O-(L-N-(benzyloxycarbonyl)-N,O-dimethyltyrosyl)-N-(tert-butoxycarbonyl)-L-serine phenacyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / triethylamine / ethyl acetate / 48 h / 20 °C

2: 63 percent / 4-(dimethylamino)pyridine; N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 20 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate;
DOI:10.1021/jo070412r