1-{4-chloro-5-[4-(4-chlorophenyl)thiazol-2-yl]-2-(3,4,5-trimethoxybenzylthio)benzenesulfonyl}-3-hydroxyguanidine

Base Information

Chemical Name:1-{4-chloro-5-[4-(4-chlorophenyl)thiazol-2-yl]-2-(3,4,5-trimethoxybenzylthio)benzenesulfonyl}-3-hydroxyguanidine
CAS No.:1398564-96-9
Molecular Formula:C₂₆H₂₄Cl₂N₄O₆S₃
Molecular Weight:655.604
Hs Code.:

Synonyms:1-{4-chloro-5-[4-(4-chlorophenyl)thiazol-2-yl]-2-(3,4,5-trimethoxybenzylthio)benzenesulfonyl}-3-hydroxyguanidine

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Chemical Property of 1-{4-chloro-5-[4-(4-chlorophenyl)thiazol-2-yl]-2-(3,4,5-trimethoxybenzylthio)benzenesulfonyl}-3-hydroxyguanidine

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Technology Process of 1-{4-chloro-5-[4-(4-chlorophenyl)thiazol-2-yl]-2-(3,4,5-trimethoxybenzylthio)benzenesulfonyl}-3-hydroxyguanidine

There total 5 articles about 1-{4-chloro-5-[4-(4-chlorophenyl)thiazol-2-yl]-2-(3,4,5-trimethoxybenzylthio)benzenesulfonyl}-3-hydroxyguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: N-{4-chloro-5-[4-(4-chlorophenyl)thiazol-2-yl]-2-(3,4,5-trimethoxybenzylthio)benzenesulfonyl}cyanamide potassium salt

: 1398564-96-9
1-{4-chloro-5-[4-(4-chlorophenyl)thiazol-2-yl]-2-(3,4,5-trimethoxybenzylthio)benzenesulfonyl}-3-hydroxyguanidine

Guidance literature:: With hydroxylamine hydrochloride; In acetonitrile; at 83 ℃;
DOI:10.1016/j.ejmech.2012.07.042

Reference yield:

: 6-chloro-3-(methylthio)-1,1-dioxo-1,4,2-benzodithiazine-7-carboxylic acid

: 1398564-96-9
1-{4-chloro-5-[4-(4-chlorophenyl)thiazol-2-yl]-2-(3,4,5-trimethoxybenzylthio)benzenesulfonyl}-3-hydroxyguanidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / benzene / Reflux

1.2: 5 - 10 °C

2.1: Lawessons reagent / toluene / 1 h / 110 °C

3.1: methanol / Reflux

4.1: ammonium hydroxide / methanol / 0 - 20 °C

5.1: potassium carbonate / tetrahydrofuran / 65 °C

6.1: hydroxylamine hydrochloride / acetonitrile / 83 °C

With Lawessons reagent; ammonium hydroxide; thionyl chloride; hydroxylamine hydrochloride; potassium carbonate; In tetrahydrofuran; methanol; toluene; acetonitrile; benzene;
DOI:10.1016/j.ejmech.2012.07.042

Reference yield:

: 156775-43-8
6-chloro-3-metylotio-1,1-diokso-1,4,2-benzoditiazyno-7-karboksyamid

: 1398564-96-9
1-{4-chloro-5-[4-(4-chlorophenyl)thiazol-2-yl]-2-(3,4,5-trimethoxybenzylthio)benzenesulfonyl}-3-hydroxyguanidine

Guidance literature:: Multi-step reaction with 5 steps

1: Lawessons reagent / toluene / 1 h / 110 °C

2: methanol / Reflux

3: ammonium hydroxide / methanol / 0 - 20 °C

4: potassium carbonate / tetrahydrofuran / 65 °C

5: hydroxylamine hydrochloride / acetonitrile / 83 °C

With Lawessons reagent; ammonium hydroxide; hydroxylamine hydrochloride; potassium carbonate; In tetrahydrofuran; methanol; toluene; acetonitrile;
DOI:10.1016/j.ejmech.2012.07.042