Ethyl 1-p-fluorophenyl-2-mercapto-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

Base Information

• Chemical Name: Ethyl 1-p-fluorophenyl-2-mercapto-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate
• CAS No.: 129579-54-0
• Molecular Formula: C₁₈H₁₂F₃NO₃S
• Molecular Weight: 379.359
• Mol file: 129579-54-0.mol

Synonyms:Ethyl 1-p-fluorophenyl-2-mercapto-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

Chemical Property of Ethyl 1-p-fluorophenyl-2-mercapto-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl 1-p-fluorophenyl-2-mercapto-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

There total 5 articles about Ethyl 1-p-fluorophenyl-2-mercapto-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Ethyl 1-p-fluorophenyl-2-methylsulfinyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (111279-77-7) → Ethyl 1-p-fluorophenyl-2-mercapto-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (129579-54-0)

Guidance literature:

With sodium hydrogensulfide; In tetrahydrofuran; Ambient temperature;

DOI:10.1002/jhet.5570270404

Reference yield:

ethyl 2,4,5-trifluorobenzoylacetate (98349-24-7) → Ethyl 1-p-fluorophenyl-2-mercapto-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (129579-54-0)

Guidance literature:

Multi-step reaction with 4 steps

2: 75 percent / NaH / tetrahydrofuran / Heating

3: 95 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / Ambient temperature

4: 86 percent / NaHS / tetrahydrofuran / Ambient temperature

With sodium hydrogensulfide; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1002/jhet.5570270404

Reference yield:

Ethyl 1-p-fluorophenyl-2-methylthio-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (111279-75-5) → Ethyl 1-p-fluorophenyl-2-mercapto-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (129579-54-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / Ambient temperature

2: 86 percent / NaHS / tetrahydrofuran / Ambient temperature

With sodium hydrogensulfide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1002/jhet.5570270404

upstream raw materials:

Ethyl 1-p-fluorophenyl-2-methylsulfinyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

ethyl 2,4,5-trifluorobenzoylacetate

Ethyl 1-p-fluorophenyl-2-methylthio-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

Ethyl 3-p-fluorophenylamino-3-methylthio-2-(2,4,5-trifluoro)benzoylacrylate

Downstream raw materials:

6,7-Difluoro-9-p-fluorophenyl-2,3,4,9-tetrahydroisothiazolo<5,4-b>quinoline-3,4-dione

6-Fluoro-7-piperazin-1-yl-9-p-fluorophenyl-2,3,4,9-tetrahydroisothiazolo<5,4-b>quinoline-3,4-dione