Ethyl 3-p-fluorophenylamino-3-methylthio-2-(2,4,5-trifluoro)benzoylacrylate

Base Information

• Chemical Name: Ethyl 3-p-fluorophenylamino-3-methylthio-2-(2,4,5-trifluoro)benzoylacrylate
• CAS No.: 111279-74-4
• Molecular Formula: C₁₉H₁₅F₄NO₃S
• Molecular Weight: 413.393
• Mol file: 111279-74-4.mol

Synonyms:Ethyl 3-p-fluorophenylamino-3-methylthio-2-(2,4,5-trifluoro)benzoylacrylate

Chemical Property of Ethyl 3-p-fluorophenylamino-3-methylthio-2-(2,4,5-trifluoro)benzoylacrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl 3-p-fluorophenylamino-3-methylthio-2-(2,4,5-trifluoro)benzoylacrylate

There total 1 articles about Ethyl 3-p-fluorophenylamino-3-methylthio-2-(2,4,5-trifluoro)benzoylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2,4,5-trifluorobenzoylacetate (98349-24-7) + 4-fluorophenyl isothiocyanate (1544-68-9) + methyl iodide (74-88-4) → Ethyl 3-p-fluorophenylamino-3-methylthio-2-(2,4,5-trifluoro)benzoylacrylate (111279-74-4)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1002/jhet.5570270404

Reference yield: 75.0%

Ethyl 3-p-fluorophenylamino-3-methylthio-2-(2,4,5-trifluoro)benzoylacrylate (111279-74-4) → Ethyl 1-p-fluorophenyl-2-methylthio-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (111279-75-5)

Guidance literature:

With sodium hydride; In tetrahydrofuran; Heating;

DOI:10.1002/jhet.5570270404

Reference yield:

Ethyl 3-p-fluorophenylamino-3-methylthio-2-(2,4,5-trifluoro)benzoylacrylate (111279-74-4) → Ethyl 1-p-fluorophenyl-2-mercapto-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (129579-54-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / NaH / tetrahydrofuran / Heating

2: 95 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / Ambient temperature

3: 86 percent / NaHS / tetrahydrofuran / Ambient temperature

With sodium hydrogensulfide; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1002/jhet.5570270404

upstream raw materials:

ethyl 2,4,5-trifluorobenzoylacetate

4-fluorophenyl isothiocyanate

methyl iodide

Downstream raw materials:

Ethyl 1-p-fluorophenyl-2-methylthio-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

Ethyl 1-p-fluorophenyl-2-mercapto-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

6,7-Difluoro-9-p-fluorophenyl-2,3,4,9-tetrahydroisothiazolo<5,4-b>quinoline-3,4-dione

Ethyl 1-p-fluorophenyl-2-methylsulfinyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate