2β-carbo-(R)-1'-mesyl-2-propoxy-3β-(4-chlorophenyl)tropane

Base Information

• Chemical Name: 2β-carbo-(R)-1'-mesyl-2-propoxy-3β-(4-chlorophenyl)tropane
• CAS No.: 262423-82-5
• Molecular Formula: C₁₉H₂₆ClNO₅S
• Molecular Weight: 415.938
• Mol file: 262423-82-5.mol

Synonyms:2β-carbo-(R)-1'-mesyl-2-propoxy-3β-(4-chlorophenyl)tropane

Chemical Property of 2β-carbo-(R)-1'-mesyl-2-propoxy-3β-(4-chlorophenyl)tropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2β-carbo-(R)-1'-mesyl-2-propoxy-3β-(4-chlorophenyl)tropane

There total 3 articles about 2β-carbo-(R)-1'-mesyl-2-propoxy-3β-(4-chlorophenyl)tropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3β-(4'-chlorophenyl)tropane-2β-carboxylic acid chloride (189949-97-1) + (R)-2-hydroxy-propyl methanesulfonate (262423-81-4) → 2β-carbo-(R)-1'-mesyl-2-propoxy-3β-(4-chlorophenyl)tropane (262423-82-5)

Guidance literature:

With triethylamine; In dichloromethane; at 10 ℃;

DOI:10.1021/jm9902234

Reference yield:

2β-carbomethoxy-3β-(4-chlorophenyl)tropane (130342-80-2) → 2β-carbo-(R)-1'-mesyl-2-propoxy-3β-(4-chlorophenyl)tropane (262423-82-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / H₂₀ / dioxane / 72 h / Heating

2: POCl₃ / 4 h / 20 °C

3: 83 percent / Et₃N / CH₂Cl₂ / 10 °C

With water; triethylamine; trichlorophosphate; In 1,4-dioxane; dichloromethane; 1: Hydrolysis / 2: Chlorination / 3: Esterification;

DOI:10.1021/jm9902234

Reference yield:

3β-(4-Chlorophenyl)-tropane-2β-carboxylic acid (140633-58-5) → 2β-carbo-(R)-1'-mesyl-2-propoxy-3β-(4-chlorophenyl)tropane (262423-82-5)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃ / 4 h / 20 °C

2: 83 percent / Et₃N / CH₂Cl₂ / 10 °C

With triethylamine; trichlorophosphate; In dichloromethane; 1: Chlorination / 2: Esterification;

DOI:10.1021/jm9902234

upstream raw materials:

3β-(4'-chlorophenyl)tropane-2β-carboxylic acid chloride

(R)-2-hydroxy-propyl methanesulfonate

2β-carbomethoxy-3β-(4-chlorophenyl)tropane

3β-(4-Chlorophenyl)-tropane-2β-carboxylic acid