140633-58-5

Basic information

• Product Name: 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-chlorophenyl)-8-methyl-, (1R,2S,3S,5S)-
• Synonyms: (1R,2S,3S,5S)-3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid;3β-(4-chlorophenyl)tropane-2β-carboxylic acid;2β-carboxylic acid-3β-(4-chlorophenyl)tropane;N-methyl-3β-(4-chlorophenyl)tropane-2β-carboxylic acid;RTI-4229-70;RTI 70;3β-(4'-chlorophenyl)tropane-2β-carboxylic acid
• CAS NO: 140633-58-5
• Molecular Formula: C15H18ClNO2
• Molecular Weight: 279.766
• Mol File: 140633-58-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 424.4±45.0 °C(Predicted)
• Density: 1.257±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-chlorophenyl)-8-methyl-, (1R,2S,3S,5S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-chlorophenyl)-8-methyl-, (1R,2S,3S,5S)-(140633-58-5)
• EPA Substance Registry System: 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-chlorophenyl)-8-methyl-, (1R,2S,3S,5S)-(140633-58-5)

Safety Data

• Hazardous Substances Data: 140633-58-5(Hazardous Substances Data)

Usage

Uses

RTI 70 is a cocaine derivative that prevent cocaine and MK-801 inhibition of nicotinic acetylcholine receptor (nAChR). Also, it is an intermediate used in the synthesis of RTI-113 (R701110), which is a 3-phenyltropane analogue that acts as a potent and selective dopamine uptake inhibitor. RTI-113 has been shown to reduce cocaine self-administration at high occupancy of dopamine transporter. Studies suggest that RTI-113 and its analogs may be useful tools for developing potential agonist therapies for cocaine dependence.

Upstream product

• 130342-80-2 2β-carbomethoxy-3β-(4-chlorophenyl)tropane 
• 7143-09-1 methyl ecgonine 
• 53-21-4 (-)-cocaine hydrochloride 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 50373-10-9 methyl ecgonidine 

Downstream Products

• 189949-97-1 3β-(4'-chlorophenyl)tropane-2β-carboxylic acid chloride 
• 262423-82-5 2β-carbo-(R)-1'-mesyl-2-propoxy-3β-(4-chlorophenyl)tropane 
• 262423-84-7 2β-carbo-(S)-1'-mesyl-2-propoxy-3β-(4-chlorophenyl)tropane 
• 1186397-11-4 1-[3β-(4-chlorophenyl)tropane-2β-carbonylamino]-2-[1-[3β-(4-chlorophenyl)tropane-2β-carbonylaminomethyl]benzen-4-yl]ethane 
• 1186397-03-4 trans-1,4-di[3β-(4-chlorophenyl)tropane-2β-carbonylamino]cyclohexane 
• 1186397-08-9 1-[3β-(4-chlorophenyl)tropane-2β-carbonylamino]-1-[1-[3β-(4-chlorophenyl)tropane-2β-carbonylamino]benzen-4-yl]methane 
• 1186397-04-5 1-[3β-(4-chlorophenyl)tropane-2β-carbonylamino]-2-[1-[3β-(4-chlorophenyl)tropane-2β-carbonyl]piperidin-4-yl]ethane 
• 1186397-06-7 1,4-di[3β-(4-chlorophenyl)tropane-2β-carbonylamino]benzene 
• 1255516-43-8 C₂₀H₂₁BrClN₃O 
• 1255516-40-5 C₂₀H₂₃BrClN₃ 
• 1255516-42-7 C₂₀H₂₃BrClN₃ 
• 1255516-44-9 C₂₀H₂₃BrClN₃ 
• 1255516-46-1 C₂₀H₂₃ClFN₃ 
• 1255516-39-2 C₂₀H₂₁BrClN₃O 

Relevant articles and documents

Synthesis of a β-CCT-lanthanide conjugate for binding the dopamine transporter

The development of a β-CCT-lanthanide conjugate that binds the dopamine transporter (DAT) with high affinity (Kd = 303 nM) is described. Contrast agents such as the one described herein could be used as molecular probes to directly study the binding of small molecules to receptors such as DAT via MRI, PET or SPECT. This journal is

Synthesis and evaluation of novel N-fluoropyridyl derivatives of tropane as potential PET imaging agents for the dopamine transporter

A series of novel N-fluoropyridyl-containing tropane derivatives were synthesized and their binding affinities for the dopamine transporter (DAT), serotonin transporter (SERT) and norepinephrine (NET) were determined via competitive radioligand binding as

Synthesis and binding affinities of 2β-(3-iodoallyloxycarbonyl)-3β-(4-substituted-aryl)tropane analogues as ligands for the dopamine transporter studies

Tropane analogues from cocaine, which is known to be one of the most reinforcing and addictive compounds, were designed, synthesized, and characterized for inhibition of presynaptic uptake of dopamine (DA) in brain. Eight new derivatives of 3β-aryl-2β-(3-iodoallyloxycarbonyl)tropanes were synthesized and tested for their potential abilities to displace [3H]2β-carbomethoxy-3β-(4-fluorophenyl)tropane (WIN 35,428) binding to the rat striatal membranes.