1-(2-chlorophenyl)methyl-2-[(4-phenyl-1,2,3-triazol-1-yl)methyl]aziridine

Base Information

Chemical Name:1-(2-chlorophenyl)methyl-2-[(4-phenyl-1,2,3-triazol-1-yl)methyl]aziridine
CAS No.:1369956-98-8
Molecular Formula:C₁₈H₁₇ClN₄
Molecular Weight:324.813
Hs Code.:

Synonyms:1-(2-chlorophenyl)methyl-2-[(4-phenyl-1,2,3-triazol-1-yl)methyl]aziridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-chlorophenyl)methyl-2-[(4-phenyl-1,2,3-triazol-1-yl)methyl]aziridine

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Technology Process of 1-(2-chlorophenyl)methyl-2-[(4-phenyl-1,2,3-triazol-1-yl)methyl]aziridine

There total 2 articles about 1-(2-chlorophenyl)methyl-2-[(4-phenyl-1,2,3-triazol-1-yl)methyl]aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1369956-91-1
2-azidomethyl-1-[(2-chlorophenyl)methyl]aziridine

: 536-74-3
phenylacetylene

: 1369956-98-8
1-(2-chlorophenyl)methyl-2-[(4-phenyl-1,2,3-triazol-1-yl)methyl]aziridine

Guidance literature:: With copper(l) iodide; In acetonitrile; at 20 ℃; for 16h; Reflux;
DOI:10.3762/bjoc.7.205

Reference yield:

: 832724-77-3
2-(bromomethyl)-1-[(2-chlorophenyl)methyl]aziridine

: 1369956-98-8
1-(2-chlorophenyl)methyl-2-[(4-phenyl-1,2,3-triazol-1-yl)methyl]aziridine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / dimethyl sulfoxide / 16 h / 20 - 80 °C

2: copper(l) iodide / acetonitrile / 16 h / 20 °C / Reflux

With copper(l) iodide; sodium azide; In dimethyl sulfoxide; acetonitrile;
DOI:10.3762/bjoc.7.205

Reference yield: 57.0%

: 1369956-98-8
1-(2-chlorophenyl)methyl-2-[(4-phenyl-1,2,3-triazol-1-yl)methyl]aziridine

: 506-59-2
N,N-dimethylammonium chloride

: 1369957-04-9
2-[(2-chlorophenyl)methyl]amino-3-dimethylamino-1-(4-phenyl-1,2,3-triazol-1-yl)propane

Guidance literature:: With dimethyl amine; In acetonitrile; at 140 ℃; for 2h; regioselective reaction; Microwave irradiation;
DOI:10.3762/bjoc.7.205