p-Nitrobenzyl (5RS,6RS)-3,7-Dioxo-6-<(RS)-1-fluoroethyl>-1-azabicyclo<3.2.0>heptane-2-carboxylate

Base Information

• Chemical Name: p-Nitrobenzyl (5RS,6RS)-3,7-Dioxo-6-<(RS)-1-fluoroethyl>-1-azabicyclo<3.2.0>heptane-2-carboxylate
• CAS No.: 118713-19-2
• Molecular Formula: C₁₆H₁₅FN₂O₆
• Molecular Weight: 350.303
• Mol file: 118713-19-2.mol

Synonyms:p-Nitrobenzyl (5RS,6RS)-3,7-Dioxo-6-<(RS)-1-fluoroethyl>-1-azabicyclo<3.2.0>heptane-2-carboxylate

Chemical Property of p-Nitrobenzyl (5RS,6RS)-3,7-Dioxo-6-<(RS)-1-fluoroethyl>-1-azabicyclo<3.2.0>heptane-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-Nitrobenzyl (5RS,6RS)-3,7-Dioxo-6-<(RS)-1-fluoroethyl>-1-azabicyclo<3.2.0>heptane-2-carboxylate

There total 1 articles about p-Nitrobenzyl (5RS,6RS)-3,7-Dioxo-6-<(RS)-1-fluoroethyl>-1-azabicyclo<3.2.0>heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

p-nitrobenzyl 4-<(3RS,4RS)-3-<(RS)-1-fluoroethyl>-2-oxoazetidinin-4-yl>-2-diazo-3-oxobutyrate → p-Nitrobenzyl (5RS,6RS)-3,7-Dioxo-6-<(RS)-1-fluoroethyl>-1-azabicyclo<3.2.0>heptane-2-carboxylate (118713-19-2)

Guidance literature:

dirhodium tetraacetate; In benzene; at 80 ℃; for 1h;

DOI:10.1248/cpb.39.335

Reference yield: 87.0%

(2S,5R)-6-((S)-1-Fluoro-ethyl)-3,7-dioxo-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester (90496-97-2,90581-01-4,97232-15-0,118713-19-2,134002-58-7) + benzylamine (100-46-9) → [(2R,3R)-2-(Benzylcarbamoyl-methyl)-3-((R)-1-fluoro-ethyl)-4-oxo-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester (98043-65-3)

Guidance literature:

In dichloromethane; for 0.5h; Ambient temperature;

Reference yield: 83.0%

ethanol (64-17-5) + (2S,5R)-6-((S)-1-Fluoro-ethyl)-3,7-dioxo-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester (90496-97-2,90581-01-4,97232-15-0,118713-19-2,134002-58-7) → [(2R,3R)-3-((R)-1-Fluoro-ethyl)-1-(4-nitro-benzyloxycarbonylmethyl)-4-oxo-azetidin-2-yl]-acetic acid ethyl ester (98043-63-1)

Guidance literature:

With pyridine; In dichloromethane; for 16h; Ambient temperature;

Downstream raw materials:

3-(Diphenoxy-phosphoryloxy)-6-(1-fluoro-ethyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

p-Nitrobenzyl (5RS,6RS)-6-<(RS)-1-Fluoroethyl>-3-<(2S)-2-p-nitrobenzyloxycarbonyl-2-p-nitrobenzyloxycarbonylamino>ethylthio-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

[(2R,3R)-3-((R)-1-Fluoro-ethyl)-2-(3-nitro-2-oxo-propyl)-4-oxo-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

[(2R,3R)-3-((R)-1-Fluoro-ethyl)-1-(4-nitro-benzyloxycarbonylmethyl)-4-oxo-azetidin-2-yl]-acetic acid ethyl ester