N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-4-(dimethylamino)butanamide

Base Information

Chemical Name:N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-4-(dimethylamino)butanamide
CAS No.:1595286-10-4
Molecular Formula:C₁₈H₁₉ClFN₅OS
Molecular Weight:407.899
Hs Code.:

Synonyms:N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-4-(dimethylamino)butanamide

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Chemical Property of N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-4-(dimethylamino)butanamide

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Technology Process of N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-4-(dimethylamino)butanamide

There total 6 articles about N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-4-(dimethylamino)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 127527-22-4
4-(N,N-dimethylamino)butanoyl chloride

: 1595286-21-7
N⁴-(3-chloro-4-fluorophenyl)thieno[2,3-d]pyrimidine-4,6-diamine

: 1595286-10-4
N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-4-(dimethylamino)butanamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2014.01.035

Reference yield:

: 4651-81-4
Methyl 2-aminothiophene-3-carboxylate

: 1595286-10-4
N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-4-(dimethylamino)butanamide

Guidance literature:: Multi-step reaction with 6 steps

1: Microwave irradiation

2: sulfuric acid; nitric acid / 2 h / 90 °C

3: trichlorophosphate; triethylamine / acetonitrile / 3 h / 70 °C

4: isopropyl alcohol / 2 h / 20 - 80 °C

5: iron; ammonium chloride / ethanol / 1 h / 45 °C

6: triethylamine / tetrahydrofuran / 0 - 20 °C

With sulfuric acid; nitric acid; iron; ammonium chloride; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.bmc.2014.01.035

Reference yield:

: 56844-41-8
6-nitrothieno[2,3-d]pyrimidin-4-ol

: 1595286-10-4
N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-4-(dimethylamino)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate; triethylamine / acetonitrile / 3 h / 70 °C

2: isopropyl alcohol / 2 h / 20 - 80 °C

3: iron; ammonium chloride / ethanol / 1 h / 45 °C

4: triethylamine / tetrahydrofuran / 0 - 20 °C

With iron; ammonium chloride; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.bmc.2014.01.035