1-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)ethane-1,2-dione

Base Information

Chemical Name:1-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)ethane-1,2-dione
CAS No.:1456534-31-8
Molecular Formula:C₂₅H₂₁N₉O₃
Molecular Weight:495.5
Hs Code.:

Synonyms:1-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)ethane-1,2-dione

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Chemical Property of 1-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)ethane-1,2-dione

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Technology Process of 1-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)ethane-1,2-dione

There total 10 articles about 1-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)ethane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 676491-47-7
2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid

: 1456534-50-1
5-phenyl-1,2,3,4-tetrahydropyridazino[3,4-d]pyrimidine

: 1456534-31-8
1-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)ethane-1,2-dione

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 2049-80-1
(2-propenyl)propanedioic acid diethyl ester

: 1456534-31-8
1-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)ethane-1,2-dione

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium; ethanol / 24 h / 0 - 20 °C / Inert atmosphere

2.1: trichlorophosphate / 3 h / 80 °C / Inert atmosphere

2.2: pH 8 - 9

3.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; 1,4-dioxane / 2 h / 20 °C

3.2: 3 h / 20 °C

4.1: ammonium chloride / 24 h / 80 °C

5.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 3 h / 100 °C / Inert atmosphere; Sealed tube

6.1: hydrogenchloride / tetrahydrofuran; water / 1 h / 45 °C

7.1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C / Inert atmosphere

8.1: trichlorophosphate / chloroform / 2 h / 0 - 20 °C / Inert atmosphere

9.1: hydrazine / tetrahydrofuran / 5 h / 60 °C / Inert atmosphere

10.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 24 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; sodium; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; hydrazine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 16019-30-0
5-(prop-2-en-1-yl)pyrimidine-4,6-diol

: 1456534-31-8
1-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)ethane-1,2-dione

Guidance literature:: Multi-step reaction with 9 steps

1.1: trichlorophosphate / 3 h / 80 °C / Inert atmosphere

1.2: pH 8 - 9

2.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; 1,4-dioxane / 2 h / 20 °C

2.2: 3 h / 20 °C

3.1: ammonium chloride / 24 h / 80 °C

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 3 h / 100 °C / Inert atmosphere; Sealed tube

5.1: hydrogenchloride / tetrahydrofuran; water / 1 h / 45 °C

6.1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C / Inert atmosphere

7.1: trichlorophosphate / chloroform / 2 h / 0 - 20 °C / Inert atmosphere

8.1: hydrazine / tetrahydrofuran / 5 h / 60 °C / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 24 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; hydrazine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide; toluene;