5-bromo-3-{1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine

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Chemical Name:5-bromo-3-{1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1350324-71-8
Molecular Formula:C₁₆H₁₁BrClF₃N₂O
Molecular Weight:420.62
Hs Code.:

Synonyms:5-bromo-3-{1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 5-bromo-3-{1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 5-bromo-3-{1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine

There total 9 articles about 5-bromo-3-{1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350322-56-3
2-Chloro-6-difluoromethoxy-3-fluorobenzaldehyde

: 1350324-77-4
5-bromo(2,3-2H₂)-1H-pyrrolo[2,3-b]pyridine

: 544-97-8
dimethyl zinc(II)

: 1350324-71-8
5-bromo-3-{1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: 2-Chloro-6-difluoromethoxy-3-fluorobenzaldehyde; 5-bromo(2,3-2H₂)-1H-pyrrolo[2,3-b]pyridine; With methanol; potassium hydroxide; at 55 ℃; for 24h; sealed tube;

With boron trifluoride diethyl etherate; In tetrahydrofuran; at -78 ℃; for 0.5h;

dimethyl zinc(II); In tetrahydrofuran; toluene; at -78 - 50 ℃; for 19h;

Reference yield:

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1350324-71-8
5-bromo-3-{1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 16 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -78 - -70 °C

2.2: 4 h / -78 - 20 °C

3.1: hydrogen chloride; water-d2 / 1,4-dioxane / 72 h / 85 °C

4.1: potassium hydroxide; methanol / 24 h / 55 °C / sealed tube

4.2: 0.5 h / -78 °C

4.3: 19 h / -78 - 50 °C

With methanol; water-d2; hydrogen chloride; sodium hydride; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; mineral oil;

Reference yield:

: 202925-07-3
2-chloro-1-fluoro-4-methoxybenzene

: 1350324-71-8
5-bromo-3-{1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tert-butyl methyl ether; hexanes / 3 h / -78 °C

1.2: 0.75 h / -60 °C

2.1: boron tribromide / dichloromethane / 17 h / -78 - 20 °C / Inert atmosphere

2.2: 0.83 h / 0 - 20 °C

3.1: ammonium nitrate / methanol / 16 h / Inert atmosphere; Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

5.1: water; acetic acid / 16 h / 50 °C

6.1: potassium hydroxide; methanol / 24 h / 55 °C / sealed tube

6.2: 0.5 h / -78 °C

6.3: 19 h / -78 - 50 °C

With ammonium nitrate; methanol; n-butyllithium; water; boron tribromide; potassium carbonate; acetic acid; potassium hydroxide; In methanol; hexanes; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide;