trans-4-{-4-[3-{(1R)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridin-5-yl]-5-methyl-1H-pyrazol-1-yl}cyclohexanol

Base Information

Chemical Name:trans-4-{-4-[3-{(1R)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridin-5-yl]-5-methyl-1H-pyrazol-1-yl}cyclohexanol
CAS No.:1350324-70-7
Molecular Formula:C₂₆H₂₆ClF₃N₄O₂
Molecular Weight:519.958
Hs Code.:

Synonyms:trans-4-{-4-[3-{(1R)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridin-5-yl]-5-methyl-1H-pyrazol-1-yl}cyclohexanol

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Chemical Property of trans-4-{-4-[3-{(1R)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridin-5-yl]-5-methyl-1H-pyrazol-1-yl}cyclohexanol

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Technology Process of trans-4-{-4-[3-{(1R)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridin-5-yl]-5-methyl-1H-pyrazol-1-yl}cyclohexanol

There total 13 articles about trans-4-{-4-[3-{(1R)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridin-5-yl]-5-methyl-1H-pyrazol-1-yl}cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350324-24-1
1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1350324-71-8
5-bromo-3-{1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine

: 1350324-69-4
trans-4-{-4-[3-{(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridin-5-yl]-5-methyl-1H-pyrazol-1-yl}cyclohexanol

: 1350324-70-7
trans-4-{-4-[3-{(1R)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridin-5-yl]-5-methyl-1H-pyrazol-1-yl}cyclohexanol

Guidance literature:: 1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 5-bromo-3-{1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 95 ℃; for 1h;

With hydrogenchloride; water; In 1,4-dioxane; at 20 - 45 ℃; for 1h;

With potassium carbonate; In 1,4-dioxane; water; at 20 ℃;

Reference yield:

: 1350322-57-4
3-chloro-2-dimethoxymethyl-4-fluorophenol

: 1350324-69-4
trans-4-{-4-[3-{(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridin-5-yl]-5-methyl-1H-pyrazol-1-yl}cyclohexanol

: 1350324-70-7
trans-4-{-4-[3-{(1R)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridin-5-yl]-5-methyl-1H-pyrazol-1-yl}cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

2.1: water; acetic acid / 16 h / 50 °C

3.1: potassium hydroxide; methanol / 24 h / 55 °C / sealed tube

3.2: 0.5 h / -78 °C

3.3: 19 h / -78 - 50 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 95 °C

4.2: 1 h / 20 - 45 °C

4.3: 20 °C

With methanol; water; potassium carbonate; acetic acid; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1263378-00-2
2-chloro-3-fluoro-6-hydroxy-benzaldehyde

: 1350324-69-4
trans-4-{-4-[3-{(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridin-5-yl]-5-methyl-1H-pyrazol-1-yl}cyclohexanol

: 1350324-70-7
trans-4-{-4-[3-{(1R)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-ethyl}(2-2H)-1H-pyrrolo[2,3-b]pyridin-5-yl]-5-methyl-1H-pyrazol-1-yl}cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium nitrate / methanol / 16 h / Inert atmosphere; Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

3.1: water; acetic acid / 16 h / 50 °C

4.1: potassium hydroxide; methanol / 24 h / 55 °C / sealed tube

4.2: 0.5 h / -78 °C

4.3: 19 h / -78 - 50 °C

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 95 °C

5.2: 1 h / 20 - 45 °C

5.3: 20 °C

With ammonium nitrate; methanol; water; potassium carbonate; acetic acid; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;