4-{5-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-phenol

Base Information

Chemical Name:4-{5-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-phenol
CAS No.:1351477-14-9
Molecular Formula:C₂₅H₂₆N₄O
Molecular Weight:398.508
Hs Code.:

Synonyms:4-{5-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-phenol

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Chemical Property of 4-{5-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-phenol

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Technology Process of 4-{5-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-phenol

There total 6 articles about 4-{5-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351478-04-0
C₃₂H₃₂N₄O₃S

: 1351477-14-9
4-{5-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-phenol

Guidance literature:: With sodium hydroxide; In methanol; acetone; at 65 ℃; for 0.5h;

Reference yield:

: 875639-74-0
4-[5-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-phenol

: 938043-30-2
1-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine

: 1351477-14-9
4-{5-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-phenol

Guidance literature:: 4-[5-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-phenol; 1-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine; With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In acetonitrile; at 150 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

With sodium hydroxide; In methanol; acetone; at 65 ℃; for 0.5h;

Reference yield:

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1351477-14-9
4-{5-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-phenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-iodo-succinimide / acetone / 0.33 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

2.2: 1.5 h / 0 °C

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 60 °C

4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

5.1: sodium hydroxide / acetone; methanol / 0.5 h / 65 °C

With N-iodo-succinimide; sodium hydride; sodium carbonate; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; acetone; acetonitrile; mineral oil;