{[(3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propyl]oxy}(triisopropyl)silane

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Chemical Name:{[(3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propyl]oxy}(triisopropyl)silane
CAS No.:1202577-96-5
Molecular Formula:C₃₀H₄₂F₄O₃Si
Molecular Weight:554.741
Hs Code.:

Synonyms:{[(3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propyl]oxy}(triisopropyl)silane

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Chemical Property of {[(3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propyl]oxy}(triisopropyl)silane

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Technology Process of {[(3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propyl]oxy}(triisopropyl)silane

There total 9 articles about {[(3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propyl]oxy}(triisopropyl)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1202577-78-3
4-{(1S)-1-ethoxy-3-[(triisopropylsilyl)oxy]propyl}phenol

: 1202577-95-4
(1S)-5-fluoro-4-(trifluoromethyl)indan-1-ol

: 1202577-96-5
{[(3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propyl]oxy}(triisopropyl)silane

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 ℃; Inert atmosphere;

Reference yield:

: 705939-73-7
methyl 3-[4-(benzyloxy)phenyl]-3-oxopropanoate

: 1202577-96-5
{[(3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propyl]oxy}(triisopropyl)silane

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; formic acid / 0 - 35 °C / Inert atmosphere

1.2: 2 h / 35 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

5.1: hydrogen / Raney nickel / tetrahydrofuran / 14 h / 20 °C

6.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 °C / Inert atmosphere

With 1H-imidazole; lithium aluminium tetrahydride; formic acid; hydrogen; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; Raney nickel; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1202577-75-0
(1S)-1-(4-benzyloxyphenyl)propan-1,3-diol

: 1202577-96-5
{[(3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propyl]oxy}(triisopropyl)silane

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3: hydrogen / Raney nickel / tetrahydrofuran / 14 h / 20 °C

4: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 °C / Inert atmosphere

With 1H-imidazole; hydrogen; sodium hydride; triphenylphosphine; diethylazodicarboxylate; Raney nickel; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;